| http://purl.uniprot.org/citations/15992821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15992821 | http://www.w3.org/2000/01/rdf-schema#comment | "The N terminus of the c-Myc oncoprotein interacts with Bin1, a ubiquitously expressed nucleocytoplasmic protein with features of a tumor suppressor. The c-Myc/Bin1 interaction is dependent on the highly conserved Myc Box 1 (MB1) sequence of c-Myc. The c-Myc/Bin1 interaction has potential regulatory significance as c-Myc-mediated transformation and apoptosis can be modulated by the expression of Bin1. Multiple splicing of the Bin1 transcript results in ubiquitous, tissue-specific and tumor-specific populations of Bin1 proteins in vivo. We report on the structural features of the interaction between c-Myc and Bin1, and describe two mechanisms by which the binding of different Bin1 isoforms to c-Myc may be regulated in cells. Our findings identify a consensus class II SH3-binding motif in c-Myc and the C-terminal SH3 domain of Bin1 as the primary structure determinants of their interaction. We present biochemical and structural evidence that tumor-specific isoforms of Bin1 are precluded from interaction with c-Myc through an intramolecular polyproline-SH3 domain interaction that inhibits the Bin1 SH3 domain from binding to c-Myc. Furthermore, c-Myc/Bin1 interaction can be inhibited by phosphorylation of c-Myc at Ser62, a functionally important residue found within the c-Myc SH3-binding motif. Our data provide a structure-based model of the c-Myc/Bin1 interaction and suggest a mode of regulation that may be important for c-Myc function as a regulator of gene transcription."xsd:string |
| http://purl.uniprot.org/citations/15992821 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jmb.2005.05.046"xsd:string |
| http://purl.uniprot.org/citations/15992821 | http://purl.uniprot.org/core/author | "Arrowsmith C.H."xsd:string |
| http://purl.uniprot.org/citations/15992821 | http://purl.uniprot.org/core/author | "Ho C.S."xsd:string |
| http://purl.uniprot.org/citations/15992821 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/15992821 | http://purl.uniprot.org/core/author | "Mao D.Y."xsd:string |
| http://purl.uniprot.org/citations/15992821 | http://purl.uniprot.org/core/author | "Sheng Y."xsd:string |
| http://purl.uniprot.org/citations/15992821 | http://purl.uniprot.org/core/author | "Szyperski T."xsd:string |
| http://purl.uniprot.org/citations/15992821 | http://purl.uniprot.org/core/author | "Pineda-Lucena A."xsd:string |
| http://purl.uniprot.org/citations/15992821 | http://purl.uniprot.org/core/author | "Muhandiram R."xsd:string |
| http://purl.uniprot.org/citations/15992821 | http://purl.uniprot.org/core/author | "Seet B.T."xsd:string |
| http://purl.uniprot.org/citations/15992821 | http://purl.uniprot.org/core/author | "Penn L.Z."xsd:string |
| http://purl.uniprot.org/citations/15992821 | http://purl.uniprot.org/core/author | "Katz S."xsd:string |
| http://purl.uniprot.org/citations/15992821 | http://purl.uniprot.org/core/author | "Laister R.C."xsd:string |
| http://purl.uniprot.org/citations/15992821 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15992821 | http://purl.uniprot.org/core/name | "J Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/15992821 | http://purl.uniprot.org/core/pages | "182-194"xsd:string |
| http://purl.uniprot.org/citations/15992821 | http://purl.uniprot.org/core/title | "A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants."xsd:string |
| http://purl.uniprot.org/citations/15992821 | http://purl.uniprot.org/core/volume | "351"xsd:string |
| http://purl.uniprot.org/citations/15992821 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15992821 |
| http://purl.uniprot.org/citations/15992821 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15992821 |
| http://purl.uniprot.org/uniprot/O00499#attribution-D60D21EE980A8ED0FFDD47986F918050 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15992821 |
| http://purl.uniprot.org/uniprot/P01106#attribution-D60D21EE980A8ED0FFDD47986F918050 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15992821 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-15992821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15992821 |