| http://purl.uniprot.org/citations/15994200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15994200 | http://www.w3.org/2000/01/rdf-schema#comment | "Papillary thyroid carcinoma (PTC) is a heterogenous disorder characterized by unique gene rearrangements and gene mutations that activate signaling pathways responsible for cellular transformation, survival, and antiapoptosis. Activation of protein kinase B (PKB) and its downstream signaling pathways appears to be an important event in thyroid tumorigenesis. In this study, we found that the thyroid-specific oncogenic RET/PTC tyrosine kinase is able to phosphorylate PKB in vitro and in vivo. RET/PTC-transfected cells showed tyrosine phosphorylation of endogenous and exogenous PKB, which was independent of phosphorylation of T308 and S473 regulated by the upstream kinases phosphoinositide-dependent kinase-1 and -2, respectively. The PKB Y315 residue, which is known to be phosphorylated by Src tyrosine kinase, was also a major site of phosphorylation by RET/PTC. RET/PTC-mediated tyrosine phosphorylation results in the activation of PKB kinase activity. The activation of PKB by RET/PTC blocked the activity of the forkhead transcription factor, FKHRL1, but a Y315F mutant of PKB failed to inhibit FKHRL1 activity. In summary, these observations suggest that RET/PTC is able to phosphorylate the Y315 residue of PKB, an event that results in maximal activation of PKB for RET/PTC-induced thyroid tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/15994200 | http://purl.org/dc/terms/identifier | "doi:10.1210/me.2005-0122"xsd:string |
| http://purl.uniprot.org/citations/15994200 | http://purl.uniprot.org/core/author | "Kim D.W."xsd:string |
| http://purl.uniprot.org/citations/15994200 | http://purl.uniprot.org/core/author | "Park S.H."xsd:string |
| http://purl.uniprot.org/citations/15994200 | http://purl.uniprot.org/core/author | "Shong M."xsd:string |
| http://purl.uniprot.org/citations/15994200 | http://purl.uniprot.org/core/author | "Park J.S."xsd:string |
| http://purl.uniprot.org/citations/15994200 | http://purl.uniprot.org/core/author | "Park K.C."xsd:string |
| http://purl.uniprot.org/citations/15994200 | http://purl.uniprot.org/core/author | "Jung H.S."xsd:string |
| http://purl.uniprot.org/citations/15994200 | http://purl.uniprot.org/core/author | "Song J.H."xsd:string |
| http://purl.uniprot.org/citations/15994200 | http://purl.uniprot.org/core/author | "Chung H.K."xsd:string |
| http://purl.uniprot.org/citations/15994200 | http://purl.uniprot.org/core/author | "Hwang J.H."xsd:string |
| http://purl.uniprot.org/citations/15994200 | http://purl.uniprot.org/core/author | "Jo Y.S."xsd:string |
| http://purl.uniprot.org/citations/15994200 | http://purl.uniprot.org/core/author | "Jo K.W."xsd:string |
| http://purl.uniprot.org/citations/15994200 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15994200 | http://purl.uniprot.org/core/name | "Mol Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/15994200 | http://purl.uniprot.org/core/pages | "2748-2759"xsd:string |
| http://purl.uniprot.org/citations/15994200 | http://purl.uniprot.org/core/title | "Regulation of protein kinase B tyrosine phosphorylation by thyroid-specific oncogenic RET/PTC kinases."xsd:string |
| http://purl.uniprot.org/citations/15994200 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/15994200 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15994200 |
| http://purl.uniprot.org/citations/15994200 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15994200 |
| http://purl.uniprot.org/uniprot/#_F5CNE9-mappedCitation-15994200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15994200 |
| http://purl.uniprot.org/uniprot/#_B3KVH4-mappedCitation-15994200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15994200 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3D6-mappedCitation-15994200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15994200 |
| http://purl.uniprot.org/uniprot/#_B4DGX8-mappedCitation-15994200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15994200 |