| http://purl.uniprot.org/citations/15994560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15994560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15994560 | http://www.w3.org/2000/01/rdf-schema#comment | "Cell signaling that culminates in posttranslational modifications directs protein activity. Here we report how multiple Ca2+-dependent phosphorylation sites within the transcription activator Ets-1 act additively to produce graded DNA binding affinity. Nuclear magnetic resonance spectroscopic analyses show that phosphorylation shifts Ets-1 from a dynamic conformation poised to bind DNA to a well-folded inhibited state. These phosphates lie in an unstructured flexible region that functions as the allosteric effector of autoinhibition. Variable phosphorylation thus serves as a "rheostat" for cell signaling to fine-tune transcription at the level of DNA binding."xsd:string |
| http://purl.uniprot.org/citations/15994560 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1111915"xsd:string |
| http://purl.uniprot.org/citations/15994560 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1111915"xsd:string |
| http://purl.uniprot.org/citations/15994560 | http://purl.uniprot.org/core/author | "Kay L.E."xsd:string |
| http://purl.uniprot.org/citations/15994560 | http://purl.uniprot.org/core/author | "Kay L.E."xsd:string |
| http://purl.uniprot.org/citations/15994560 | http://purl.uniprot.org/core/author | "Lee G.M."xsd:string |
| http://purl.uniprot.org/citations/15994560 | http://purl.uniprot.org/core/author | "Lee G.M."xsd:string |
| http://purl.uniprot.org/citations/15994560 | http://purl.uniprot.org/core/author | "McIntosh L.P."xsd:string |
| http://purl.uniprot.org/citations/15994560 | http://purl.uniprot.org/core/author | "McIntosh L.P."xsd:string |
| http://purl.uniprot.org/citations/15994560 | http://purl.uniprot.org/core/author | "Kang H.S."xsd:string |
| http://purl.uniprot.org/citations/15994560 | http://purl.uniprot.org/core/author | "Kang H.S."xsd:string |
| http://purl.uniprot.org/citations/15994560 | http://purl.uniprot.org/core/author | "Graves B.J."xsd:string |
| http://purl.uniprot.org/citations/15994560 | http://purl.uniprot.org/core/author | "Graves B.J."xsd:string |
| http://purl.uniprot.org/citations/15994560 | http://purl.uniprot.org/core/author | "Nelson M.L."xsd:string |
| http://purl.uniprot.org/citations/15994560 | http://purl.uniprot.org/core/author | "Nelson M.L."xsd:string |
| http://purl.uniprot.org/citations/15994560 | http://purl.uniprot.org/core/author | "Pufall M.A."xsd:string |
| http://purl.uniprot.org/citations/15994560 | http://purl.uniprot.org/core/author | "Pufall M.A."xsd:string |
| http://purl.uniprot.org/citations/15994560 | http://purl.uniprot.org/core/author | "Velyvis A."xsd:string |
| http://purl.uniprot.org/citations/15994560 | http://purl.uniprot.org/core/author | "Velyvis A."xsd:string |
| http://purl.uniprot.org/citations/15994560 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15994560 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15994560 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/15994560 | http://purl.uniprot.org/core/name | "Science"xsd:string |