| http://purl.uniprot.org/citations/15994948 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15994948 | http://www.w3.org/2000/01/rdf-schema#comment | "The PTEN tumor suppressor gene is frequently inactivated in human tumors, including prostate cancer. Based on the Cre/loxP system, we generated a novel mouse prostate cancer model by targeted inactivation of the Pten gene. In this model, Cre recombinase was expressed under the control of the prostate-specific antigen (PSA) promoter. Conditional biallelic and monoallelic Pten knock-out mice were viable and Pten recombination was prostate-specific. Mouse cohorts were systematically characterized at 4 to 5, 7 to 9, and 10 to 14 months. A slightly increased proliferation rate of epithelial cells was observed in all prostate lobes of monoallelic Pten knock-out mice (PSA-Cre;Pten-loxP/+), but minimal pathologic changes were detected. All homozygous knock-out mice (PSA-Cre;Pten-loxP/loxP) showed an increased size of the luminal epithelial cells, large areas of hyperplasia, focal prostate intraepithelial neoplasia lesions and an increased prostate weight at 4 to 5 months. More extensive prostate intraepithelial neoplasia and focal microinvasion occurred at 7 to 9 months; invasive prostate carcinoma was detected in all male PSA-Cre;Pten-loxP/loxP mice at 10 to 14 months. At 15 to 16 months, a rare lymph node metastasis was found. In hyperplastic cells and in tumor cells, the expression of phospho-AKT was up-regulated. In hyperplastic and tumor cells, expression of luminal epithelial cell cytokeratins was up-regulated; tumor cells were negative for basal epithelial cell cytokeratins. Androgen receptor expression remained detectable at all stages of tumor development. The up-regulation of phospho-AKT correlated with an increased proliferation rate of the epithelial cells, but not with a reduced apoptosis."xsd:string |
| http://purl.uniprot.org/citations/15994948 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-04-4519"xsd:string |
| http://purl.uniprot.org/citations/15994948 | http://purl.uniprot.org/core/author | "Ma X."xsd:string |
| http://purl.uniprot.org/citations/15994948 | http://purl.uniprot.org/core/author | "Krimpenfort P."xsd:string |
| http://purl.uniprot.org/citations/15994948 | http://purl.uniprot.org/core/author | "Berns A."xsd:string |
| http://purl.uniprot.org/citations/15994948 | http://purl.uniprot.org/core/author | "Trapman J."xsd:string |
| http://purl.uniprot.org/citations/15994948 | http://purl.uniprot.org/core/author | "de Krijger R."xsd:string |
| http://purl.uniprot.org/citations/15994948 | http://purl.uniprot.org/core/author | "Vermeij M."xsd:string |
| http://purl.uniprot.org/citations/15994948 | http://purl.uniprot.org/core/author | "Ziel-van der Made A.C."xsd:string |
| http://purl.uniprot.org/citations/15994948 | http://purl.uniprot.org/core/author | "van der Korput H.A."xsd:string |
| http://purl.uniprot.org/citations/15994948 | http://purl.uniprot.org/core/author | "Cleutjens K.B."xsd:string |
| http://purl.uniprot.org/citations/15994948 | http://purl.uniprot.org/core/author | "van der Kwast T.H."xsd:string |
| http://purl.uniprot.org/citations/15994948 | http://purl.uniprot.org/core/author | "Autar B."xsd:string |
| http://purl.uniprot.org/citations/15994948 | http://purl.uniprot.org/core/author | "van Duijn P."xsd:string |
| http://purl.uniprot.org/citations/15994948 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15994948 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/15994948 | http://purl.uniprot.org/core/pages | "5730-5739"xsd:string |
| http://purl.uniprot.org/citations/15994948 | http://purl.uniprot.org/core/title | "Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis."xsd:string |
| http://purl.uniprot.org/citations/15994948 | http://purl.uniprot.org/core/volume | "65"xsd:string |
| http://purl.uniprot.org/citations/15994948 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15994948 |
| http://purl.uniprot.org/citations/15994948 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15994948 |
| http://purl.uniprot.org/uniprot/O08586#attribution-C2A0FBBE903E2D96A7216054A78CCD19 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15994948 |
| http://purl.uniprot.org/uniprot/#_A0A024QYR9-mappedCitation-15994948 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15994948 |
| http://purl.uniprot.org/uniprot/#_A0A1V0DNR6-mappedCitation-15994948 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15994948 |