| http://purl.uniprot.org/citations/15996661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15996661 | http://www.w3.org/2000/01/rdf-schema#comment | "Ets-1 is a cellular homologue of the product of the viral ets oncogene of the E26 virus, and it functions as a tissue-specific transcription factor. It plays an important role in cell proliferation, differentiation, lymphoid cell development, transformation, angiogenesis, and apoptosis. Ets-1 controls the expression of critical genes involved in these processes by binding to ets binding sites present in the transcriptional regulatory regions. Here, we transiently overexpressed Ets-1 in MCF-7 and comprehensively searched for potential downstream targets of Ets-1 by cDNA microarray analysis. The expressions of several interferon-related genes including STAT1 and Nmi were augmented by the overexpression of Ets-1. RT-PCR and Western blotting confirmed the increase in the levels of STAT1 and Nmi mRNA and protein. In contrast, Ets-1 siRNA decreased the expression of STAT1 and Nmi proteins. As in our transient transfection experiments, stable overexpression of Ets-1, also increased the protein expression of STAT1 and Nmi in MCF-7 cells. Taken together, our results indicate that STAT1 and Nmi are downstream targets of Ets-1 in MCF-7 human breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/15996661 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2005.06.011"xsd:string |
| http://purl.uniprot.org/citations/15996661 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/15996661 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/15996661 | http://purl.uniprot.org/core/author | "Park C."xsd:string |
| http://purl.uniprot.org/citations/15996661 | http://purl.uniprot.org/core/author | "Park K."xsd:string |
| http://purl.uniprot.org/citations/15996661 | http://purl.uniprot.org/core/author | "Ryu K.J."xsd:string |
| http://purl.uniprot.org/citations/15996661 | http://purl.uniprot.org/core/author | "Jung H.H."xsd:string |
| http://purl.uniprot.org/citations/15996661 | http://purl.uniprot.org/core/author | "Kang S.A."xsd:string |
| http://purl.uniprot.org/citations/15996661 | http://purl.uniprot.org/core/author | "Kang W.K."xsd:string |
| http://purl.uniprot.org/citations/15996661 | http://purl.uniprot.org/core/author | "Nam D.H."xsd:string |
| http://purl.uniprot.org/citations/15996661 | http://purl.uniprot.org/core/author | "Sung K."xsd:string |
| http://purl.uniprot.org/citations/15996661 | http://purl.uniprot.org/core/author | "Im Y.H."xsd:string |
| http://purl.uniprot.org/citations/15996661 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15996661 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/15996661 | http://purl.uniprot.org/core/pages | "3941-3946"xsd:string |
| http://purl.uniprot.org/citations/15996661 | http://purl.uniprot.org/core/title | "STAT1 and Nmi are downstream targets of Ets-1 transcription factor in MCF-7 human breast cancer cell."xsd:string |
| http://purl.uniprot.org/citations/15996661 | http://purl.uniprot.org/core/volume | "579"xsd:string |
| http://purl.uniprot.org/citations/15996661 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15996661 |
| http://purl.uniprot.org/citations/15996661 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15996661 |
| http://purl.uniprot.org/uniprot/#_A8K683-mappedCitation-15996661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15996661 |
| http://purl.uniprot.org/uniprot/#_A0A510GDC6-mappedCitation-15996661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15996661 |
| http://purl.uniprot.org/uniprot/#_A4UCT9-mappedCitation-15996661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15996661 |
| http://purl.uniprot.org/uniprot/#_A5D905-mappedCitation-15996661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15996661 |