| http://purl.uniprot.org/citations/15998721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15998721 | http://www.w3.org/2000/01/rdf-schema#comment | "The med-1 and med-2 genes encode a pair of essentially identical GATA factor-related transcription factors that have been proposed to be necessary for specification of the C. elegans endoderm (intestine or E lineage) as well as part of the C. elegans mesoderm. med-1 and med-2 are proposed to be the direct downstream targets and the principal effectors of the maternally provided SKN-1 transcription factor; med-1 and med-2 would thus occupy the pivotal interface between maternal and zygotic control of gene expression. The conclusion that med-1 and med-2 are necessary for C. elegans endoderm specification was based on a partially penetrant (approximately 50%) loss of endoderm markers produced by RNA-mediated interference (RNAi). To determine whether this partial penetrance reflects: (i) inefficient RNAi against early zygotic transcripts, (ii) experimental uncertainty in the expected level of endoderm loss in skn-1 nulls, or (iii) additional redundancy in the pathway of endoderm specification, we constructed worm strains that segregate embryos lacking both the med-1 gene (because of a gene-specific deletion) and the med-2 gene (using either of two chromosomal deficiencies). Contrary to expectations, we observe that only approximately 3-20% of med-2(-); med-1(-) embryos do not express markers of endoderm differentiation. Furthermore, we found no evidence for a maternal contribution of the med genes to endoderm specification. We conclude that the major pathway(s) for endoderm specification in C. elegans must be independent of the med-1 and med-2 genes."xsd:string |
| http://purl.uniprot.org/citations/15998721 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.105.044909"xsd:string |
| http://purl.uniprot.org/citations/15998721 | http://purl.uniprot.org/core/author | "Goszczynski B."xsd:string |
| http://purl.uniprot.org/citations/15998721 | http://purl.uniprot.org/core/author | "McGhee J.D."xsd:string |
| http://purl.uniprot.org/citations/15998721 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15998721 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/15998721 | http://purl.uniprot.org/core/pages | "545-555"xsd:string |
| http://purl.uniprot.org/citations/15998721 | http://purl.uniprot.org/core/title | "Reevaluation of the role of the med-1 and med-2 genes in specifying the Caenorhabditis elegans endoderm."xsd:string |
| http://purl.uniprot.org/citations/15998721 | http://purl.uniprot.org/core/volume | "171"xsd:string |
| http://purl.uniprot.org/citations/15998721 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15998721 |
| http://purl.uniprot.org/citations/15998721 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15998721 |
| http://purl.uniprot.org/uniprot/#_G5EF25-mappedCitation-15998721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15998721 |
| http://purl.uniprot.org/uniprot/#_G5EF71-mappedCitation-15998721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15998721 |
| http://purl.uniprot.org/uniprot/G5EF71 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15998721 |
| http://purl.uniprot.org/uniprot/G5EF25 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15998721 |