| http://purl.uniprot.org/citations/15998742 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15998742 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15998742 | http://www.w3.org/2000/01/rdf-schema#comment | "Agrobacterium tumefaciens infects plants and induces the formation of tumors called "crown galls" by integrating the transferred-DNA (T-DNA) region of the Ti-plasmid into the plant nuclear genome. Tumors are formed because the T-DNA encodes enzymes that modify the synthesis of two plant growth hormones, auxin and cytokinin (CK). Here, we show that a CK biosynthesis enzyme, Tmr, which is encoded by the Agrobacterium T-DNA region, is targeted to and functions in plastids of infected plant cells, despite having no typical plastid-targeting sequence. Evidence is provided that Tmr is an adenosine phosphate-isopentenyltransferase (IPT) that creates a new CK biosynthesis bypass by using 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBDP) as a substrate. Unlike in the conventional CK biosynthesis pathway in plants, trans-zeatin-type CKs are produced directly without the requirement for P450 monooxygenase-mediated hydroxylation. Consistent with the plastid localization of Tmr, HMBDP is an intermediate in the methylerythritol phosphate pathway, a plastid-localized biosynthesis route for universal isoprenoid precursors. These results demonstrate that A. tumefaciens modifies CK biosynthesis by sending a key enzyme into plastids of the host plant to promote tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/15998742 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0500793102"xsd:string |
| http://purl.uniprot.org/citations/15998742 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0500793102"xsd:string |
| http://purl.uniprot.org/citations/15998742 | http://purl.uniprot.org/core/author | "Kojima M."xsd:string |
| http://purl.uniprot.org/citations/15998742 | http://purl.uniprot.org/core/author | "Kojima M."xsd:string |
| http://purl.uniprot.org/citations/15998742 | http://purl.uniprot.org/core/author | "Kamiya Y."xsd:string |
| http://purl.uniprot.org/citations/15998742 | http://purl.uniprot.org/core/author | "Kamiya Y."xsd:string |
| http://purl.uniprot.org/citations/15998742 | http://purl.uniprot.org/core/author | "Okada K."xsd:string |
| http://purl.uniprot.org/citations/15998742 | http://purl.uniprot.org/core/author | "Okada K."xsd:string |
| http://purl.uniprot.org/citations/15998742 | http://purl.uniprot.org/core/author | "Sakakibara H."xsd:string |
| http://purl.uniprot.org/citations/15998742 | http://purl.uniprot.org/core/author | "Sakakibara H."xsd:string |
| http://purl.uniprot.org/citations/15998742 | http://purl.uniprot.org/core/author | "Yamaya T."xsd:string |
| http://purl.uniprot.org/citations/15998742 | http://purl.uniprot.org/core/author | "Yamaya T."xsd:string |
| http://purl.uniprot.org/citations/15998742 | http://purl.uniprot.org/core/author | "Yamaguchi S."xsd:string |
| http://purl.uniprot.org/citations/15998742 | http://purl.uniprot.org/core/author | "Yamaguchi S."xsd:string |
| http://purl.uniprot.org/citations/15998742 | http://purl.uniprot.org/core/author | "Asami T."xsd:string |
| http://purl.uniprot.org/citations/15998742 | http://purl.uniprot.org/core/author | "Asami T."xsd:string |
| http://purl.uniprot.org/citations/15998742 | http://purl.uniprot.org/core/author | "Takei K."xsd:string |
| http://purl.uniprot.org/citations/15998742 | http://purl.uniprot.org/core/author | "Takei K."xsd:string |
| http://purl.uniprot.org/citations/15998742 | http://purl.uniprot.org/core/author | "Kasahara H."xsd:string |
| http://purl.uniprot.org/citations/15998742 | http://purl.uniprot.org/core/author | "Kasahara H."xsd:string |
| http://purl.uniprot.org/citations/15998742 | http://purl.uniprot.org/core/author | "Ueda N."xsd:string |
| http://purl.uniprot.org/citations/15998742 | http://purl.uniprot.org/core/author | "Ueda N."xsd:string |