| http://purl.uniprot.org/citations/16001398 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16001398 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in the myosin-VIIa (MYO7a) gene cause human Usher disease, characterized by hearing impairment and progressive retinal degeneration. In the retina, myosin-VIIa is highly expressed in the retinal pigment epithelium, where it plays a role in the positioning of melanosomes and other digestion organelles. Using a human cultured retinal pigmented epithelia cell line, ARPE-19, as a model system, we have found that a population of myosin-VIIa is associated with cathepsin D- and Rab7-positive lysosomes. Association of myosin-VIIa with lysosomes was Rab7 independent, as dominant negative and dominant active versions of Rab7 did not disrupt myosin-VIIa recruitment to lysosomes. Association of myosin-VIIa with lysosomes was also independent of the actin and microtubule cytoskeleton. Myosin-VIIa copurified with lysosomes on density gradients, and fractionation and extraction experiments suggested that it was tightly associated with the lysosome surface. These studies suggest that myosin-VIIa is a lysosome motor."xsd:string |
| http://purl.uniprot.org/citations/16001398 | http://purl.org/dc/terms/identifier | "doi:10.1002/cm.20080"xsd:string |
| http://purl.uniprot.org/citations/16001398 | http://purl.uniprot.org/core/author | "Orten D.J."xsd:string |
| http://purl.uniprot.org/citations/16001398 | http://purl.uniprot.org/core/author | "Bucci C."xsd:string |
| http://purl.uniprot.org/citations/16001398 | http://purl.uniprot.org/core/author | "Hasson T."xsd:string |
| http://purl.uniprot.org/citations/16001398 | http://purl.uniprot.org/core/author | "Warren C.M."xsd:string |
| http://purl.uniprot.org/citations/16001398 | http://purl.uniprot.org/core/author | "Soni L.E."xsd:string |
| http://purl.uniprot.org/citations/16001398 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16001398 | http://purl.uniprot.org/core/name | "Cell Motil Cytoskeleton"xsd:string |
| http://purl.uniprot.org/citations/16001398 | http://purl.uniprot.org/core/pages | "13-26"xsd:string |
| http://purl.uniprot.org/citations/16001398 | http://purl.uniprot.org/core/title | "The unconventional myosin-VIIa associates with lysosomes."xsd:string |
| http://purl.uniprot.org/citations/16001398 | http://purl.uniprot.org/core/volume | "62"xsd:string |
| http://purl.uniprot.org/citations/16001398 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16001398 |
| http://purl.uniprot.org/citations/16001398 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16001398 |
| http://purl.uniprot.org/uniprot/Q13402#attribution-E2A00EB158D66ABB9EB4F8CA47EDBE06 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16001398 |