| http://purl.uniprot.org/citations/16002688 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16002688 | http://www.w3.org/2000/01/rdf-schema#comment | "We demonstrated in this study the critical role of NKT cells in the lethal ileitis induced in C57BL/6 mice after infection with Toxoplasma gondii. This intestinal inflammation is caused by overproduction of IFN-gamma in the lamina propria. The implication of NKT cells was confirmed by the observation that NKT cell-deficient mice (Jalpha281(-/-)) are more resistant than C57BL/6 mice to the development of lethal ileitis. Jalpha281(-/-) mice failed to overexpress IFN-gamma in the intestine early after infection. This detrimental effect of NKT cells is blocked by treatment with alpha-galactosylceramide, which prevents death in C57BL/6, but not in Jalpha281(-/-), mice. This protective effect is characterized by a shift in cytokine production by NKT cells toward a Th2 profile and correlates with an increased number of mesenteric Foxp3 lymphocytes. Using chimeric mice in which only NKT cells are deficient in the IL-10 gene and mice treated with anti-CD25 mAb, we identified regulatory T cells as the source of the IL-10 required for manifestation of the protective effect of alpha-galactosylceramide treatment. Our results highlight the participation of NKT cells in the parasite clearance by shifting the cytokine profile toward a Th1 pattern and simultaneously to immunopathological manifestation when this Th1 immune response remains uncontrolled."xsd:string |
| http://purl.uniprot.org/citations/16002688 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.175.2.899"xsd:string |
| http://purl.uniprot.org/citations/16002688 | http://purl.uniprot.org/core/author | "Miyake S."xsd:string |
| http://purl.uniprot.org/citations/16002688 | http://purl.uniprot.org/core/author | "Kasper L.H."xsd:string |
| http://purl.uniprot.org/citations/16002688 | http://purl.uniprot.org/core/author | "Yamamura T."xsd:string |
| http://purl.uniprot.org/citations/16002688 | http://purl.uniprot.org/core/author | "Darche S."xsd:string |
| http://purl.uniprot.org/citations/16002688 | http://purl.uniprot.org/core/author | "Louis J.A."xsd:string |
| http://purl.uniprot.org/citations/16002688 | http://purl.uniprot.org/core/author | "Ronet C."xsd:string |
| http://purl.uniprot.org/citations/16002688 | http://purl.uniprot.org/core/author | "Buzoni-Gatel D."xsd:string |
| http://purl.uniprot.org/citations/16002688 | http://purl.uniprot.org/core/author | "Leite de Moraes M."xsd:string |
| http://purl.uniprot.org/citations/16002688 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16002688 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16002688 | http://purl.uniprot.org/core/pages | "899-908"xsd:string |
| http://purl.uniprot.org/citations/16002688 | http://purl.uniprot.org/core/title | "NKT cells are critical for the initiation of an inflammatory bowel response against Toxoplasma gondii."xsd:string |
| http://purl.uniprot.org/citations/16002688 | http://purl.uniprot.org/core/volume | "175"xsd:string |
| http://purl.uniprot.org/citations/16002688 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16002688 |
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| http://purl.uniprot.org/uniprot/#_P11609-mappedCitation-16002688 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16002688 |