| http://purl.uniprot.org/citations/16002707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16002707 | http://www.w3.org/2000/01/rdf-schema#comment | "Sle is a susceptibility locus for systemic autoimmunity derived from the lupus-prone NZM2410 mouse. The New Zealand White-derived suppressive modifier Sles1 was identified as a specific modifier of Sle1 and prevents the development of IgG anti-chromatin autoantibodies mediated by Sle1 on the C57BL/6 (B6) background. Fine mapping of Sles1 with truncated congenic intervals localizes it to a approximately 956-kb segment of mouse chromosome 17. Sles1 completely abrogates the development of activated T and B cell populations in B6.Sle1. Despite this suppression of the Sle1-mediated cell surface activation phenotypes, B6.Sle1 Sles1 splenic B cells still exhibit intrinsic ERK phosphorylation. Classic genetic complementation tests using the nonautoimmmune 129/SvJ mouse suggests that this strain possesses a Sles1 allele complementary to that of New Zealand White, as evidenced by the lack of glomerulonephritis, splenomegaly, and antinuclear autoantibody production seen in (129 x B6.Sle1 Sles1)F(1)s. These findings localize and characterize the suppressive properties of Sles1 and implicate 129 as a useful strain for aiding in the identification of this elusive epistatic modifier gene."xsd:string |
| http://purl.uniprot.org/citations/16002707 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.175.2.1062"xsd:string |
| http://purl.uniprot.org/citations/16002707 | http://purl.uniprot.org/core/author | "Zhou X.J."xsd:string |
| http://purl.uniprot.org/citations/16002707 | http://purl.uniprot.org/core/author | "Subramanian S."xsd:string |
| http://purl.uniprot.org/citations/16002707 | http://purl.uniprot.org/core/author | "Liu K."xsd:string |
| http://purl.uniprot.org/citations/16002707 | http://purl.uniprot.org/core/author | "Wakeland E.K."xsd:string |
| http://purl.uniprot.org/citations/16002707 | http://purl.uniprot.org/core/author | "Yim Y.S."xsd:string |
| http://purl.uniprot.org/citations/16002707 | http://purl.uniprot.org/core/author | "Tus K."xsd:string |
| http://purl.uniprot.org/citations/16002707 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16002707 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16002707 | http://purl.uniprot.org/core/pages | "1062-1072"xsd:string |
| http://purl.uniprot.org/citations/16002707 | http://purl.uniprot.org/core/title | "Epistatic suppression of systemic lupus erythematosus: fine mapping of Sles1 to less than 1 mb."xsd:string |
| http://purl.uniprot.org/citations/16002707 | http://purl.uniprot.org/core/volume | "175"xsd:string |
| http://purl.uniprot.org/citations/16002707 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16002707 |
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