| http://purl.uniprot.org/citations/16005298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16005298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16005298 | http://www.w3.org/2000/01/rdf-schema#comment | "Ca(2+) signaling in nonexcitable cells is typically initiated by receptor-triggered production of inositol-1,4,5-trisphosphate and the release of Ca(2+) from intracellular stores. An elusive signaling process senses the Ca(2+) store depletion and triggers the opening of plasma membrane Ca(2+) channels. The resulting sustained Ca(2+) signals are required for many physiological responses, such as T cell activation and differentiation. Here, we monitored receptor-triggered Ca(2+) signals in cells transfected with siRNAs against 2,304 human signaling proteins, and we identified two proteins required for Ca(2+)-store-depletion-mediated Ca(2+) influx, STIM1 and STIM2. These proteins have a single transmembrane region with a putative Ca(2+) binding domain in the lumen of the endoplasmic reticulum. Ca(2+) store depletion led to a rapid translocation of STIM1 into puncta that accumulated near the plasma membrane. Introducing a point mutation in the STIM1 Ca(2+) binding domain resulted in prelocalization of the protein in puncta, and this mutant failed to respond to store depletion. Our study suggests that STIM proteins function as Ca(2+) store sensors in the signaling pathway connecting Ca(2+) store depletion to Ca(2+) influx."xsd:string |
| http://purl.uniprot.org/citations/16005298 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2005.05.055"xsd:string |
| http://purl.uniprot.org/citations/16005298 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2005.05.055"xsd:string |
| http://purl.uniprot.org/citations/16005298 | http://purl.uniprot.org/core/author | "Meyer T."xsd:string |
| http://purl.uniprot.org/citations/16005298 | http://purl.uniprot.org/core/author | "Meyer T."xsd:string |
| http://purl.uniprot.org/citations/16005298 | http://purl.uniprot.org/core/author | "Jones J.T."xsd:string |
| http://purl.uniprot.org/citations/16005298 | http://purl.uniprot.org/core/author | "Jones J.T."xsd:string |
| http://purl.uniprot.org/citations/16005298 | http://purl.uniprot.org/core/author | "Kim M.L."xsd:string |
| http://purl.uniprot.org/citations/16005298 | http://purl.uniprot.org/core/author | "Kim M.L."xsd:string |
| http://purl.uniprot.org/citations/16005298 | http://purl.uniprot.org/core/author | "Liou J."xsd:string |
| http://purl.uniprot.org/citations/16005298 | http://purl.uniprot.org/core/author | "Liou J."xsd:string |
| http://purl.uniprot.org/citations/16005298 | http://purl.uniprot.org/core/author | "Heo W.D."xsd:string |
| http://purl.uniprot.org/citations/16005298 | http://purl.uniprot.org/core/author | "Heo W.D."xsd:string |
| http://purl.uniprot.org/citations/16005298 | http://purl.uniprot.org/core/author | "Ferrell J.E. Jr."xsd:string |
| http://purl.uniprot.org/citations/16005298 | http://purl.uniprot.org/core/author | "Ferrell J.E. Jr."xsd:string |
| http://purl.uniprot.org/citations/16005298 | http://purl.uniprot.org/core/author | "Myers J.W."xsd:string |
| http://purl.uniprot.org/citations/16005298 | http://purl.uniprot.org/core/author | "Myers J.W."xsd:string |
| http://purl.uniprot.org/citations/16005298 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16005298 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16005298 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/16005298 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/16005298 | http://purl.uniprot.org/core/pages | "1235-1241"xsd:string |
| http://purl.uniprot.org/citations/16005298 | http://purl.uniprot.org/core/pages | "1235-1241"xsd:string |