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http://purl.uniprot.org/citations/16005430http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16005430http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16005430http://www.w3.org/2000/01/rdf-schema#comment"We demonstrate that the product of the yeast open reading frame YML005w is required for wybutosine (yW) formation in the phenylalanine-accepting tRNA of the yeast Saccharomyces cerevisiae. tRNA isolated from a deletion mutant of the YML005w gene accumulates 4-demethylwyosine (ImG-14), a precursor lacking three of the methyl groups of the yW hypermodified base. Since the amino acid sequence of the YML005w gene contains the signature motifs of the seven beta-strand methyltransferases, we now designate the gene TRM12 for tRNA methyltransferase. Using pulse-chase labeling of intact yeast cells with S-adenosyl-L-[methyl-(3)H]methionine, we show that the methylesterified form of yW is metabolically stable."xsd:string
http://purl.uniprot.org/citations/16005430http://purl.org/dc/terms/identifier"doi:10.1016/j.bbrc.2005.06.111"xsd:string
http://purl.uniprot.org/citations/16005430http://purl.org/dc/terms/identifier"doi:10.1016/j.bbrc.2005.06.111"xsd:string
http://purl.uniprot.org/citations/16005430http://purl.uniprot.org/core/author"Clarke S."xsd:string
http://purl.uniprot.org/citations/16005430http://purl.uniprot.org/core/author"Clarke S."xsd:string
http://purl.uniprot.org/citations/16005430http://purl.uniprot.org/core/author"Kalhor H.R."xsd:string
http://purl.uniprot.org/citations/16005430http://purl.uniprot.org/core/author"Kalhor H.R."xsd:string
http://purl.uniprot.org/citations/16005430http://purl.uniprot.org/core/author"Penjwini M."xsd:string
http://purl.uniprot.org/citations/16005430http://purl.uniprot.org/core/author"Penjwini M."xsd:string
http://purl.uniprot.org/citations/16005430http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/16005430http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/16005430http://purl.uniprot.org/core/name"Biochem. Biophys. Res. Commun."xsd:string
http://purl.uniprot.org/citations/16005430http://purl.uniprot.org/core/name"Biochem. Biophys. Res. Commun."xsd:string
http://purl.uniprot.org/citations/16005430http://purl.uniprot.org/core/pages"433-440"xsd:string
http://purl.uniprot.org/citations/16005430http://purl.uniprot.org/core/pages"433-440"xsd:string
http://purl.uniprot.org/citations/16005430http://purl.uniprot.org/core/title"A novel methyltransferase required for the formation of the hypermodified nucleoside wybutosine in eucaryotic tRNA."xsd:string
http://purl.uniprot.org/citations/16005430http://purl.uniprot.org/core/title"A novel methyltransferase required for the formation of the hypermodified nucleoside wybutosine in eucaryotic tRNA."xsd:string
http://purl.uniprot.org/citations/16005430http://purl.uniprot.org/core/volume"334"xsd:string
http://purl.uniprot.org/citations/16005430http://purl.uniprot.org/core/volume"334"xsd:string
http://purl.uniprot.org/citations/16005430http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16005430
http://purl.uniprot.org/citations/16005430http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16005430
http://purl.uniprot.org/citations/16005430http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16005430
http://purl.uniprot.org/citations/16005430http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16005430