| http://purl.uniprot.org/citations/16006511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16006511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16006511 | http://www.w3.org/2000/01/rdf-schema#comment | "WNK (with no lysine [K]) kinases are serine-threonine protein kinases with an atypical placement of the catalytic lysine. Intronic deletions increase the expression of WNK1 in humans and cause pseudohypoaldosteronism type II, a form of hypertension. WNKs have been linked to ion carriers, but the underlying regulatory mechanisms are unknown. Here, we report a mechanism for the control of ion permeability by WNK1. We show that WNK1 activates the serum- and glucocorticoid-inducible protein kinase SGK1, leading to activation of the epithelial sodium channel. Increased channel activity induced by WNK1 depends on SGK1 and the E3 ubiquitin ligase Nedd4-2. This finding provides compelling evidence that this molecular mechanism contributes to the pathogenesis of hypertension in pseudohypoaldosteronism type II caused by WNK1 and, possibly, in other forms of hypertension."xsd:string |
| http://purl.uniprot.org/citations/16006511 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0504422102"xsd:string |
| http://purl.uniprot.org/citations/16006511 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0504422102"xsd:string |
| http://purl.uniprot.org/citations/16006511 | http://purl.uniprot.org/core/author | "Li X.J."xsd:string |
| http://purl.uniprot.org/citations/16006511 | http://purl.uniprot.org/core/author | "Li X.J."xsd:string |
| http://purl.uniprot.org/citations/16006511 | http://purl.uniprot.org/core/author | "Lee B.H."xsd:string |
| http://purl.uniprot.org/citations/16006511 | http://purl.uniprot.org/core/author | "Lee B.H."xsd:string |
| http://purl.uniprot.org/citations/16006511 | http://purl.uniprot.org/core/author | "Cobb M.H."xsd:string |
| http://purl.uniprot.org/citations/16006511 | http://purl.uniprot.org/core/author | "Cobb M.H."xsd:string |
| http://purl.uniprot.org/citations/16006511 | http://purl.uniprot.org/core/author | "Xu B.E."xsd:string |
| http://purl.uniprot.org/citations/16006511 | http://purl.uniprot.org/core/author | "Xu B.E."xsd:string |
| http://purl.uniprot.org/citations/16006511 | http://purl.uniprot.org/core/author | "Huang C.L."xsd:string |
| http://purl.uniprot.org/citations/16006511 | http://purl.uniprot.org/core/author | "Huang C.L."xsd:string |
| http://purl.uniprot.org/citations/16006511 | http://purl.uniprot.org/core/author | "Ortega B."xsd:string |
| http://purl.uniprot.org/citations/16006511 | http://purl.uniprot.org/core/author | "Ortega B."xsd:string |
| http://purl.uniprot.org/citations/16006511 | http://purl.uniprot.org/core/author | "Chu P.Y."xsd:string |
| http://purl.uniprot.org/citations/16006511 | http://purl.uniprot.org/core/author | "Chu P.Y."xsd:string |
| http://purl.uniprot.org/citations/16006511 | http://purl.uniprot.org/core/author | "English J.M."xsd:string |
| http://purl.uniprot.org/citations/16006511 | http://purl.uniprot.org/core/author | "English J.M."xsd:string |
| http://purl.uniprot.org/citations/16006511 | http://purl.uniprot.org/core/author | "Stippec S."xsd:string |
| http://purl.uniprot.org/citations/16006511 | http://purl.uniprot.org/core/author | "Stippec S."xsd:string |
| http://purl.uniprot.org/citations/16006511 | http://purl.uniprot.org/core/author | "Lazrak A."xsd:string |
| http://purl.uniprot.org/citations/16006511 | http://purl.uniprot.org/core/author | "Lazrak A."xsd:string |