| http://purl.uniprot.org/citations/16007096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16007096 | http://www.w3.org/2000/01/rdf-schema#comment | "Suppressor of cytokine signaling (SOCS) 3 attenuates proinflammatory signaling mediated by the signal transducer and activator of transcription (STAT) family of proteins. But acute inflammation can occur after exposure to pathogen-derived inducers staphylococcal enterotoxin B (SEB) and lipopolysaccharide (LPS), or the lectin concanavalin A (ConA), suggesting that physiologic levels of SOCS3 are insufficient to stem proinflammatory signaling under pathogenic circumstances. To test this hypothesis, we developed recombinant cell-penetrating forms of SOCS3 (CP-SOCS3) for intracellular delivery to counteract SEB-, LPS- and ConA-induced inflammation. We found that CP-SOCS3 was distributed in multiple organs within 2 h and persisted for at least 8 h in leukocytes and lymphocytes. CP-SOCS3 protected animals from lethal effects of SEB and LPS by reducing production of inflammatory cytokines and attenuating liver apoptosis and hemorrhagic necrosis. It also reduced ConA-induced liver apoptosis. Thus, replenishing the intracellular stores of SOCS3 with CP-SOCS3 effectively suppresses the devastating effects of acute inflammation."xsd:string |
| http://purl.uniprot.org/citations/16007096 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm1269"xsd:string |
| http://purl.uniprot.org/citations/16007096 | http://purl.uniprot.org/core/author | "Liu D."xsd:string |
| http://purl.uniprot.org/citations/16007096 | http://purl.uniprot.org/core/author | "Yao S."xsd:string |
| http://purl.uniprot.org/citations/16007096 | http://purl.uniprot.org/core/author | "Jo D."xsd:string |
| http://purl.uniprot.org/citations/16007096 | http://purl.uniprot.org/core/author | "Hawiger J."xsd:string |
| http://purl.uniprot.org/citations/16007096 | http://purl.uniprot.org/core/author | "Collins R.D."xsd:string |
| http://purl.uniprot.org/citations/16007096 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16007096 | http://purl.uniprot.org/core/name | "Nat Med"xsd:string |
| http://purl.uniprot.org/citations/16007096 | http://purl.uniprot.org/core/pages | "892-898"xsd:string |
| http://purl.uniprot.org/citations/16007096 | http://purl.uniprot.org/core/title | "Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis."xsd:string |
| http://purl.uniprot.org/citations/16007096 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/16007096 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16007096 |
| http://purl.uniprot.org/citations/16007096 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16007096 |
| http://purl.uniprot.org/uniprot/#_O35718-mappedCitation-16007096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16007096 |
| http://purl.uniprot.org/uniprot/#_Q3U9J8-mappedCitation-16007096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16007096 |
| http://purl.uniprot.org/uniprot/Q3U9J8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16007096 |
| http://purl.uniprot.org/uniprot/O35718 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16007096 |