| http://purl.uniprot.org/citations/16007223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16007223 | http://www.w3.org/2000/01/rdf-schema#comment | "Neurofibromatosis type 2 (NF2) is the most commonly mutated gene in benign tumors of the human nervous system such as schwannomas and meningiomas. The NF2 gene encodes a protein called schwannomin or merlin, which is involved in regulating cell growth and proliferation through protein-protein interactions with various cellular proteins. In order to better understand the mechanism by which merlin exerts its function, yeast two-hybrid screening was performed and Ral guanine nucleotide dissociation stimulator (RalGDS), a downstream molecule of Ras, was identified as a merlin-binding protein. The direct interaction between merlin and RalGDS was confirmed both in vitro and in the NIH3T3 cells. The domain analyses revealed that the broad C-terminal region of merlin (aa 141-595) is necessary for the interaction with the C-terminal Ras-binding domain (RBD) of RalGDS. Functional studies showed that merlin inhibits the RalGDS-induced RalA activation, the colony formation and the cell migration in mammalian cells. These results suggest that merlin can function as a tumor suppressor by inhibiting the RalGDS-mediated oncogenic signals."xsd:string |
| http://purl.uniprot.org/citations/16007223 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1208633"xsd:string |
| http://purl.uniprot.org/citations/16007223 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/16007223 | http://purl.uniprot.org/core/author | "Kim Y.H."xsd:string |
| http://purl.uniprot.org/citations/16007223 | http://purl.uniprot.org/core/author | "Lee K.H."xsd:string |
| http://purl.uniprot.org/citations/16007223 | http://purl.uniprot.org/core/author | "Lee J.Y."xsd:string |
| http://purl.uniprot.org/citations/16007223 | http://purl.uniprot.org/core/author | "Lee W.K."xsd:string |
| http://purl.uniprot.org/citations/16007223 | http://purl.uniprot.org/core/author | "Kim S.W."xsd:string |
| http://purl.uniprot.org/citations/16007223 | http://purl.uniprot.org/core/author | "Choi B.H."xsd:string |
| http://purl.uniprot.org/citations/16007223 | http://purl.uniprot.org/core/author | "Lim Y."xsd:string |
| http://purl.uniprot.org/citations/16007223 | http://purl.uniprot.org/core/author | "Ryu C.H."xsd:string |
| http://purl.uniprot.org/citations/16007223 | http://purl.uniprot.org/core/author | "Rha H.K."xsd:string |
| http://purl.uniprot.org/citations/16007223 | http://purl.uniprot.org/core/author | "Hwang T.K."xsd:string |
| http://purl.uniprot.org/citations/16007223 | http://purl.uniprot.org/core/author | "Jun T.Y."xsd:string |
| http://purl.uniprot.org/citations/16007223 | http://purl.uniprot.org/core/author | "Lee K.H.'"xsd:string |
| http://purl.uniprot.org/citations/16007223 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16007223 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/16007223 | http://purl.uniprot.org/core/pages | "5355-5364"xsd:string |
| http://purl.uniprot.org/citations/16007223 | http://purl.uniprot.org/core/title | "The merlin tumor suppressor interacts with Ral guanine nucleotide dissociation stimulator and inhibits its activity."xsd:string |
| http://purl.uniprot.org/citations/16007223 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/16007223 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16007223 |
| http://purl.uniprot.org/citations/16007223 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16007223 |
| http://purl.uniprot.org/uniprot/#_B3KPK6-mappedCitation-16007223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16007223 |
| http://purl.uniprot.org/uniprot/#_Q12967-mappedCitation-16007223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16007223 |