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http://purl.uniprot.org/citations/16009107http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Objective

To study the therapeutic mechanism of salvianolic acid B (SA-B) in treating hepatic fibrosis.

Methods

Twenty-four Wistar rats were randomly divided into 3 groups: normal control group, untreated group and SA-B-treated group. Rats in the untreated and SA-B-treated groups were injected intraperitoneally with 0.5% dimethylnitrosamine (DMN) for 4 weeks, daily for 3 days each week at a dose of 10 microg/kg, to induce hepatic fibrosis. Then, rats in the SA-B-treated group were given SA-B orally for another 4 weeks. Hydroxyproline (Hyp) contents in liver tissue of the rats in 3 groups were determined with HCl hydrolysis, and collagen type I, transforming growth factor-beta 1 (TGF-beta1), transforming growth factor-beta receptor type I (TbetaRI) and transforming growth factor-beta receptor type II (TbetaRII) were detected by Western blotting.

Results

The Hyp content and the expressions of collagen type I, TGF-beta1, TbetaRI and TbetaRII in the liver tissue of rats in the untreated group increased significantly as compared with those in the normal control group, while those in SA-B-treated group decreased significantly as compared with those in the untreated group.

Conclusion

The therapeutic mechanism of SA-B in treating hepatic fibrosis may be related to inhibiting the expressions of TGF-beta1 and its receptors."xsd:string
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http://purl.uniprot.org/citations/16009107http://purl.uniprot.org/core/author"Liu P."xsd:string
http://purl.uniprot.org/citations/16009107http://purl.uniprot.org/core/author"Zhu D.Y."xsd:string
http://purl.uniprot.org/citations/16009107http://purl.uniprot.org/core/author"Liu C.H."xsd:string
http://purl.uniprot.org/citations/16009107http://purl.uniprot.org/core/author"Hu Y.Y."xsd:string
http://purl.uniprot.org/citations/16009107http://purl.uniprot.org/core/author"Wang X.N."xsd:string
http://purl.uniprot.org/citations/16009107http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/16009107http://purl.uniprot.org/core/name"Zhong Xi Yi Jie He Xue Bao"xsd:string
http://purl.uniprot.org/citations/16009107http://purl.uniprot.org/core/pages"286-289"xsd:string
http://purl.uniprot.org/citations/16009107http://purl.uniprot.org/core/title"[Effects of salvianolic acid B on expressions of TGF-beta1 and its receptors in liver of rats with dimethylnitrosamine-induced hepatic fibrosis]."xsd:string
http://purl.uniprot.org/citations/16009107http://purl.uniprot.org/core/volume"3"xsd:string
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