DESCRIBE <http://purl.uniprot.org/citations/16012930>

Subject	Predicate	Object
http://purl.uniprot.org/citations/16012930	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16012930	http://www.w3.org/2000/01/rdf-schema#comment	" Background & aims Although it has been shown that des-acyl ghrelin decreases food intake and gastric emptying, no previous studies have examined the effects of des-acyl ghrelin on physiologic fed and fasted motor activity in the gastrointestinal tract. Methods We examined the effects of intraperitoneal (IP) administration of des-acyl ghrelin on food intake and the effects of intracerebroventricular (ICV) or intravenous (IV) administration of des-acyl ghrelin on gastroduodenal motility using freely moving conscious rat models. The brain nuclei responding to these effects were examined by c-fos immunohistochemistry of the brain sections. Results IP injection of des-acyl ghrelin decreased food intake, and this effect was not altered by capsaicin treatment. IP injection of des-acyl ghrelin enhanced c-fos expression in the arcuate and paraventricular nucleus but not in the nucleus of the solitary tract. Both ICV and IV injection of des-acyl ghrelin disrupted fasted motor activity in the antrum but not in the duodenum. Changes in gastric motility induced by IV injection of des-acyl ghrelin were completely antagonized by ICV injection of a selective corticotropin-releasing factor (CRF) 2 receptor antagonist; however, the CRF 1 receptor antagonist had no effects. Conclusions The results suggest that des-acyl ghrelin decreases food intake and disrupts the fasted motor activity of the antrum in freely moving conscious rats. Peripheral des-acyl ghrelin may induce this function by direct activation of brain receptor by crossing the blood-brain barrier but not by the activation of vagal afferent pathways. In the brain, CRF 2 receptor, but not CRF 1 receptor, is involved in this action."xsd:string
http://purl.uniprot.org/citations/16012930	http://purl.org/dc/terms/identifier	"doi:10.1053/j.gastro.2005.04.015"xsd:string
http://purl.uniprot.org/citations/16012930	http://purl.uniprot.org/core/author	"Chen C.Y."xsd:string
http://purl.uniprot.org/citations/16012930	http://purl.uniprot.org/core/author	"Fujino K."xsd:string
http://purl.uniprot.org/citations/16012930	http://purl.uniprot.org/core/author	"Kato I."xsd:string
http://purl.uniprot.org/citations/16012930	http://purl.uniprot.org/core/author	"Chen C.C."xsd:string
http://purl.uniprot.org/citations/16012930	http://purl.uniprot.org/core/author	"Ueno N."xsd:string
http://purl.uniprot.org/citations/16012930	http://purl.uniprot.org/core/author	"Inui A."xsd:string
http://purl.uniprot.org/citations/16012930	http://purl.uniprot.org/core/author	"Asakawa A."xsd:string
http://purl.uniprot.org/citations/16012930	http://purl.uniprot.org/core/author	"Fujimiya M."xsd:string
http://purl.uniprot.org/citations/16012930	http://purl.uniprot.org/core/date	"2005"xsd:gYear
http://purl.uniprot.org/citations/16012930	http://purl.uniprot.org/core/name	"Gastroenterology"xsd:string
http://purl.uniprot.org/citations/16012930	http://purl.uniprot.org/core/pages	"8-25"xsd:string
http://purl.uniprot.org/citations/16012930	http://purl.uniprot.org/core/title	"Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats."xsd:string
http://purl.uniprot.org/citations/16012930	http://purl.uniprot.org/core/volume	"129"xsd:string
http://purl.uniprot.org/citations/16012930	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/16012930
http://purl.uniprot.org/citations/16012930	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/16012930
http://purl.uniprot.org/uniprot/P47866#attribution-4FF9929654672268394AD1DF461F0101	http://purl.uniprot.org/core/source	http://purl.uniprot.org/citations/16012930
http://purl.uniprot.org/uniprot/#_A0A0G2K9U2-mappedCitation-16012930	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16012930
http://purl.uniprot.org/uniprot/#_D4A5C4-mappedCitation-16012930	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16012930
http://purl.uniprot.org/uniprot/#_A0A8I5ZNG6-mappedCitation-16012930	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16012930
http://purl.uniprot.org/uniprot/#_P47866-mappedCitation-16012930	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16012930
http://purl.uniprot.org/uniprot/A0A8I5ZNG6	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/16012930
http://purl.uniprot.org/uniprot/D4A5C4	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/16012930