| http://purl.uniprot.org/citations/16014379 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16014379 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16014379 | http://www.w3.org/2000/01/rdf-schema#comment | "Pontin and Reptin previously were identified as nuclear beta-catenin interaction partners that antagonistically modulate beta-catenin transcriptional activity. In this study, Hint1/PKCI, a member of the evolutionary conserved family of histidine triad proteins, was characterised as a new interaction partner of Pontin and Reptin. Pull-down assays and co-immunoprecipitation experiments show that Hint1/PKCI directly binds to Pontin and Reptin. The Hint1/PKCI-binding site was mapped to amino acids 214-295 and 218-289 in Pontin and Reptin, respectively. Conversely, Pontin and Reptin bind to the N-terminus of Hint1/PKCI. Moreover, by its interaction with Pontin and Reptin, Hint1/PKCI is associated with the LEF-1/TCF-beta-catenin transcription complex. In this context, Hint1/PKCI acts as a negative regulator of TCF-beta-catenin transcriptional activity in Wnt-transfected cells and in SW480 colon carcinoma cells as shown in reporter gene assays. Consistent with these observations, Hint1/PKCI represses expression of the endogenous target genes cyclin D1 and axin2 whereas knockdown of Hint1/PKCI by RNA interference increases their expression. Disruption of the Pontin/Reptin complex appears to mediate this modulatory effect of Hint1/PKCI on TCF-beta-catenin-mediated transcription. These data now provide a molecular mechanism to explain the tumor suppressor function of Hint1/PKCI recently suggested from the analysis of Hint1/PKCI knockout mice."xsd:string |
| http://purl.uniprot.org/citations/16014379 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.02437"xsd:string |
| http://purl.uniprot.org/citations/16014379 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.02437"xsd:string |
| http://purl.uniprot.org/citations/16014379 | http://purl.uniprot.org/core/author | "Weiske J."xsd:string |
| http://purl.uniprot.org/citations/16014379 | http://purl.uniprot.org/core/author | "Weiske J."xsd:string |
| http://purl.uniprot.org/citations/16014379 | http://purl.uniprot.org/core/author | "Huber O."xsd:string |
| http://purl.uniprot.org/citations/16014379 | http://purl.uniprot.org/core/author | "Huber O."xsd:string |
| http://purl.uniprot.org/citations/16014379 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16014379 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16014379 | http://purl.uniprot.org/core/name | "J. Cell Sci."xsd:string |
| http://purl.uniprot.org/citations/16014379 | http://purl.uniprot.org/core/name | "J. Cell Sci."xsd:string |
| http://purl.uniprot.org/citations/16014379 | http://purl.uniprot.org/core/pages | "3117-3129"xsd:string |
| http://purl.uniprot.org/citations/16014379 | http://purl.uniprot.org/core/pages | "3117-3129"xsd:string |
| http://purl.uniprot.org/citations/16014379 | http://purl.uniprot.org/core/title | "The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-beta-catenin-mediated transcription."xsd:string |
| http://purl.uniprot.org/citations/16014379 | http://purl.uniprot.org/core/title | "The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-beta-catenin-mediated transcription."xsd:string |
| http://purl.uniprot.org/citations/16014379 | http://purl.uniprot.org/core/volume | "118"xsd:string |
| http://purl.uniprot.org/citations/16014379 | http://purl.uniprot.org/core/volume | "118"xsd:string |
| http://purl.uniprot.org/citations/16014379 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16014379 |
| http://purl.uniprot.org/citations/16014379 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16014379 |
| http://purl.uniprot.org/citations/16014379 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16014379 |
| http://purl.uniprot.org/citations/16014379 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16014379 |
| http://purl.uniprot.org/uniprot/P49773 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/16014379 |
| http://purl.uniprot.org/uniprot/Q9Y265 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/16014379 |