DESCRIBE <http://purl.uniprot.org/citations/16018977>

Subject	Predicate	Object
http://purl.uniprot.org/citations/16018977	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16018977	http://www.w3.org/2000/01/rdf-schema#comment	" Background The 5-hydroxytryptamine7 receptor (5-HT7) is implicated in circadian rhythm phase resetting, and 5-HT7 receptor-selective antagonists alter rapid eye movement (REM) sleep parameters in a pattern opposite from those in patients with clinical depression. Methods As sleep, circadian rhythm, and mood regulation are related, we examined 5-HT7 receptor knockout mice in two behavioral models of depression. The forced swim and tail suspension tests are highly predictive for antidepressant drug activity. Results Unmedicated 5-HT7-/-mice showed decreased immobility in both tests, consistent with an antidepressantlike behavior. The selective 5-HT7 receptor antagonist SB-269970 also decreased immobility. The selective serotonin reuptake inhibitor citalopram, a widely used antidepressant, decreased immobility in both 5-HT7+/+ and 5-HT7-/-mice in the tail suspension test, suggesting that it utilizes an independent mechanism. The 5-HT7-/-mice spent less time in and had less frequent episodes of REM sleep, also consistent with an antidepressantlike state. Conclusions The 5-HT7 receptor might have a role in mood disorders and antagonists might have therapeutic value as antidepressants."xsd:string
http://purl.uniprot.org/citations/16018977	http://purl.org/dc/terms/identifier	"doi:10.1016/j.biopsych.2005.05.012"xsd:string
http://purl.uniprot.org/citations/16018977	http://purl.uniprot.org/core/author	"Sutcliffe J.G."xsd:string
http://purl.uniprot.org/citations/16018977	http://purl.uniprot.org/core/author	"Henriksen S.J."xsd:string
http://purl.uniprot.org/citations/16018977	http://purl.uniprot.org/core/author	"Huitron-Resendiz S."xsd:string
http://purl.uniprot.org/citations/16018977	http://purl.uniprot.org/core/author	"Hedlund P.B."xsd:string
http://purl.uniprot.org/citations/16018977	http://purl.uniprot.org/core/date	"2005"xsd:gYear
http://purl.uniprot.org/citations/16018977	http://purl.uniprot.org/core/name	"Biol Psychiatry"xsd:string
http://purl.uniprot.org/citations/16018977	http://purl.uniprot.org/core/pages	"831-837"xsd:string
http://purl.uniprot.org/citations/16018977	http://purl.uniprot.org/core/title	"5-HT7 receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern."xsd:string
http://purl.uniprot.org/citations/16018977	http://purl.uniprot.org/core/volume	"58"xsd:string
http://purl.uniprot.org/citations/16018977	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/16018977
http://purl.uniprot.org/citations/16018977	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/16018977
http://purl.uniprot.org/uniprot/#_E9Q1X2-mappedCitation-16018977	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16018977
http://purl.uniprot.org/uniprot/#_B6VJS2-mappedCitation-16018977	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16018977
http://purl.uniprot.org/uniprot/#_B6VJS3-mappedCitation-16018977	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16018977
http://purl.uniprot.org/uniprot/#_E9Q4Q7-mappedCitation-16018977	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16018977
http://purl.uniprot.org/uniprot/#_P32304-mappedCitation-16018977	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16018977
http://purl.uniprot.org/uniprot/#_Q3UUR3-mappedCitation-16018977	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16018977
http://purl.uniprot.org/uniprot/#_Q6ST19-mappedCitation-16018977	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16018977
http://purl.uniprot.org/uniprot/#_Q6ST20-mappedCitation-16018977	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16018977
http://purl.uniprot.org/uniprot/Q6ST20	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/16018977
http://purl.uniprot.org/uniprot/B6VJS3	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/16018977
http://purl.uniprot.org/uniprot/Q3UUR3	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/16018977