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http://purl.uniprot.org/citations/16020694http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16020694http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16020694http://www.w3.org/2000/01/rdf-schema#comment"Certain pathogens, such as Mycobacterium tuberculosis, survive within the hostile intracellular environment of a macrophage. To identify host factors required for mycobacterial entry and survival within macrophages, we performed a genomewide RNA interference screen in Drosophila macrophage-like cells, using Mycobacterium fortuitum. We identified factors required for general phagocytosis, as well as those needed specifically for mycobacterial infection. One specific factor, Peste (Pes), is a CD36 family member required for uptake of mycobacteria, but not Escherichia coli or Staphylococcus aureus. Moreover, mammalian class B scavenger receptors (SRs) conferred uptake of bacteria into nonphagocytic cells, with SR-BI and SR-BII uniquely mediating uptake of M. fortuitum, which suggests a conserved role for class B SRs in pattern recognition and innate immunity."xsd:string
http://purl.uniprot.org/citations/16020694http://purl.org/dc/terms/identifier"doi:10.1126/science.1116006"xsd:string
http://purl.uniprot.org/citations/16020694http://purl.org/dc/terms/identifier"doi:10.1126/science.1116006"xsd:string
http://purl.uniprot.org/citations/16020694http://purl.uniprot.org/core/author"Perrimon N."xsd:string
http://purl.uniprot.org/citations/16020694http://purl.uniprot.org/core/author"Perrimon N."xsd:string
http://purl.uniprot.org/citations/16020694http://purl.uniprot.org/core/author"Rubin E.J."xsd:string
http://purl.uniprot.org/citations/16020694http://purl.uniprot.org/core/author"Rubin E.J."xsd:string
http://purl.uniprot.org/citations/16020694http://purl.uniprot.org/core/author"Philips J.A."xsd:string
http://purl.uniprot.org/citations/16020694http://purl.uniprot.org/core/author"Philips J.A."xsd:string
http://purl.uniprot.org/citations/16020694http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/16020694http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/16020694http://purl.uniprot.org/core/name"Science"xsd:string
http://purl.uniprot.org/citations/16020694http://purl.uniprot.org/core/name"Science"xsd:string
http://purl.uniprot.org/citations/16020694http://purl.uniprot.org/core/pages"1251-1253"xsd:string
http://purl.uniprot.org/citations/16020694http://purl.uniprot.org/core/pages"1251-1253"xsd:string
http://purl.uniprot.org/citations/16020694http://purl.uniprot.org/core/title"Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection."xsd:string
http://purl.uniprot.org/citations/16020694http://purl.uniprot.org/core/title"Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection."xsd:string
http://purl.uniprot.org/citations/16020694http://purl.uniprot.org/core/volume"309"xsd:string
http://purl.uniprot.org/citations/16020694http://purl.uniprot.org/core/volume"309"xsd:string
http://purl.uniprot.org/citations/16020694http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16020694
http://purl.uniprot.org/citations/16020694http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16020694
http://purl.uniprot.org/citations/16020694http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16020694
http://purl.uniprot.org/citations/16020694http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16020694