| http://purl.uniprot.org/citations/16030015 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16030015 | http://www.w3.org/2000/01/rdf-schema#comment | "Filamin A (FLNa) cross-links actin filaments (F-actin) into three-dimensional gels in cells, attaches F-actin to membrane proteins, and is a scaffold that collects numerous and diverse proteins. We report that Ca(2+)-calmodulin binds the actin-binding domain (ABD) of FLNa and dissociates FLNa from F-actin, thereby dissolving FLNa.F-actin gels. The FLNa ABD has two calponin homology domains (CH1 and CH2) separated by a linker. Recombinant CH1 but neither FLNa nor its ABD binds Ca(2+)-calmodulin in the absence of F-actin. Extending recombinant CH1 to include the negatively charged region linker domain makes it, like full-length FLNa, unable to bind Ca(2+)-calmodulin. Ca(2+)-calmodulin does, however, dissociate the FLNa ABD from F-actin provided that the CH2 domain is present. These findings identify the first evidence for direct regulation of FLNa, implicating a mechanism whereby Ca(2+)-calmodulin selectively targets the FLNa.F-actin complex."xsd:string |
| http://purl.uniprot.org/citations/16030015 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m502203200"xsd:string |
| http://purl.uniprot.org/citations/16030015 | http://purl.uniprot.org/core/author | "Nakamura F."xsd:string |
| http://purl.uniprot.org/citations/16030015 | http://purl.uniprot.org/core/author | "Hartwig J.H."xsd:string |
| http://purl.uniprot.org/citations/16030015 | http://purl.uniprot.org/core/author | "Stossel T.P."xsd:string |
| http://purl.uniprot.org/citations/16030015 | http://purl.uniprot.org/core/author | "Szymanski P.T."xsd:string |
| http://purl.uniprot.org/citations/16030015 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16030015 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/16030015 | http://purl.uniprot.org/core/pages | "32426-32433"xsd:string |
| http://purl.uniprot.org/citations/16030015 | http://purl.uniprot.org/core/title | "Ca2+ and calmodulin regulate the binding of filamin A to actin filaments."xsd:string |
| http://purl.uniprot.org/citations/16030015 | http://purl.uniprot.org/core/volume | "280"xsd:string |
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