| http://purl.uniprot.org/citations/16033425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16033425 | http://www.w3.org/2000/01/rdf-schema#comment | "Age-related changes in the gene expression of the transcription factors, Phox2a and 2b, and two marker proteins, norepinephrine transporter (NET) and dopamine beta-hydroxylase (DBH), of noradrenergic neurons were characterized in the locus coeruleus (LC) and adrenal glands using in situ hybridization. Analysis of changes was performed in rats that were 1-23 months of age. Compared to 1-month-old rats, there was a 62% increase of Phox2a messenger RNA (mRNA) in the LC of 3-month-old rats, and a decline of 37% in 23-month-old rats. In contrast, levels of Phox2b mRNA in the LC remained unchanged in 3-month-old rats, but declined to a 30% reduction in 23-month-old rats. Interestingly, mRNA levels of NET in the LC decreased with increasing age to a reduction of 29%, 30% and 43% in 3-, 8- and 23-month-old rats, respectively. Similarly, DBH mRNA in the LC declined with increasing age to a 56% reduction in 23-month-old rats. mRNA levels of Phox2a, Phox2b, NET and DBH in the adrenal medulla of 23-month-old rats were significantly lower than those of 1-month-old rats. Semi-quantitative reverse transcription assays of the same genes yielded data similar to in situ hybridization experiments, with beta-actin mRNA levels being unchanged across the ages. Taken together, these data reveal that reduced Phox2 mRNAs in the LC and adrenal medulla of aging rats are accompanied by a coincidental decline in mRNA levels of NET and DBH and suggest a possible relationship between Phox2 genes and the marker genes in noradrenergic neurons after birth."xsd:string |
| http://purl.uniprot.org/citations/16033425 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1471-4159.2005.03245.x"xsd:string |
| http://purl.uniprot.org/citations/16033425 | http://purl.uniprot.org/core/author | "Kim K.S."xsd:string |
| http://purl.uniprot.org/citations/16033425 | http://purl.uniprot.org/core/author | "Wang W.P."xsd:string |
| http://purl.uniprot.org/citations/16033425 | http://purl.uniprot.org/core/author | "Iyo A.H."xsd:string |
| http://purl.uniprot.org/citations/16033425 | http://purl.uniprot.org/core/author | "Zhu M.Y."xsd:string |
| http://purl.uniprot.org/citations/16033425 | http://purl.uniprot.org/core/author | "Ordway G.A."xsd:string |
| http://purl.uniprot.org/citations/16033425 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16033425 | http://purl.uniprot.org/core/name | "J Neurochem"xsd:string |
| http://purl.uniprot.org/citations/16033425 | http://purl.uniprot.org/core/pages | "828-838"xsd:string |
| http://purl.uniprot.org/citations/16033425 | http://purl.uniprot.org/core/title | "Age-associated changes in mRNA levels of Phox2, norepinephrine transporter and dopamine beta-hydroxylase in the locus coeruleus and adrenal glands of rats."xsd:string |
| http://purl.uniprot.org/citations/16033425 | http://purl.uniprot.org/core/volume | "94"xsd:string |
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