| http://purl.uniprot.org/citations/16034073 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16034073 | http://www.w3.org/2000/01/rdf-schema#comment | "HLA-E is an MHC class Ib molecule that binds nonamer peptides derived from the leader sequence of MHC class 1a molecules and is the major ligand for CD94/NKG2 receptors found on NK and T cells. Using the MHC class Ia-null cell line 721.221, we find that surface HLA-E increases following heat shock at 42 degrees C and NK cell-mediated lysis is inhibited using heat-stressed 721.221 targets. We have used mass spectrometry to identify and sequence a novel peptide from HLA-E following heat shock, ALALVRMLI, derived from the transmembrane domain of the human ATP-binding cassette protein, multidrug resistance-associated protein, MRP7. Pulsing 721.221 targets with synthetic MRP7 peptide results in strong inhibition of NK cell-mediated lysis that is reversible using anti-CD94 and anti-class I mAbs. This report is the first to identify a non-MHC leader inhibitory peptide bound to HLA-E and provides insight into the immunoregulatory role of HLA-E during cell stress."xsd:string |
| http://purl.uniprot.org/citations/16034073 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.175.3.1383"xsd:string |
| http://purl.uniprot.org/citations/16034073 | http://purl.uniprot.org/core/author | "Cotter R.J."xsd:string |
| http://purl.uniprot.org/citations/16034073 | http://purl.uniprot.org/core/author | "Kalb S.R."xsd:string |
| http://purl.uniprot.org/citations/16034073 | http://purl.uniprot.org/core/author | "Soloski M.J."xsd:string |
| http://purl.uniprot.org/citations/16034073 | http://purl.uniprot.org/core/author | "Wooden S.L."xsd:string |
| http://purl.uniprot.org/citations/16034073 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16034073 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16034073 | http://purl.uniprot.org/core/pages | "1383-1387"xsd:string |
| http://purl.uniprot.org/citations/16034073 | http://purl.uniprot.org/core/title | "Cutting edge: HLA-E binds a peptide derived from the ATP-binding cassette transporter multidrug resistance-associated protein 7 and inhibits NK cell-mediated lysis."xsd:string |
| http://purl.uniprot.org/citations/16034073 | http://purl.uniprot.org/core/volume | "175"xsd:string |
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