| http://purl.uniprot.org/citations/16037384 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16037384 | http://www.w3.org/2000/01/rdf-schema#comment | "IGF-II is a potent mitogen and inhibitor of apoptosis in breast cancer. Regulation of IGF-II is complex and includes inhibition by tumor suppressors, stimulation by oncogenes, and imprinting and hormonal regulation by estrogens. Resveratrol (RSV) is a phytoestrogen that displays estrogen-like agonistic and antagonistic activity. Recent studies have shown that RSV inhibits the growth of breast cancer cells and may represent a potent agent in chemopreventive therapy. Because 17beta-estradiol regulates IGF-II, we hypothesized that RSV may have a similar effect on IGF-II. The present study was designed to examine whether: 1) RSV modulates IGF-II in breast cancer cells; 2) regulation of IGF-II by RSV is dependent on the ER status; and 3) IGF-II (not IGF-I) mediates RSV effects on breast cancer cells. Treatment of MCF-7 and T47D cells with RSV (10(-6) M) caused stimulation of precursor IGF-II mRNA and protein; this effect was blocked by coincubation with 17beta-estradiol (10(-9) M). Cell growth stimulated by RSV (10(-6) M) was blocked by addition of a blocking IGF-I receptor antibody, or the antiestrogen tamoxifen (10(-7) M). In contrast, RSV treatment (10(-4) M) inhibited IGF-II secretion and cell growth in MCF-7 and T47D cells. No increase in IGF-II levels is seen in estrogen receptor (-) MCF-10 cells, even though cell growth was inhibited by RSV 10(-4) M and precursor IGF-II blocked the inhibitory effect of resveratrol. No change in IGF-I was observed with RSV treatment (10(-6) to 10(-4) M). Our study demonstrates that RSV regulates IGF-II and that IGF-II mediates RSV effect on cell survival and growth in breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/16037384 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2004-1344"xsd:string |
| http://purl.uniprot.org/citations/16037384 | http://purl.uniprot.org/core/author | "Vyas S."xsd:string |
| http://purl.uniprot.org/citations/16037384 | http://purl.uniprot.org/core/author | "Asmerom Y."xsd:string |
| http://purl.uniprot.org/citations/16037384 | http://purl.uniprot.org/core/author | "De Leon D.D."xsd:string |
| http://purl.uniprot.org/citations/16037384 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16037384 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/16037384 | http://purl.uniprot.org/core/pages | "4224-4233"xsd:string |
| http://purl.uniprot.org/citations/16037384 | http://purl.uniprot.org/core/title | "Resveratrol regulates insulin-like growth factor-II in breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/16037384 | http://purl.uniprot.org/core/volume | "146"xsd:string |
| http://purl.uniprot.org/citations/16037384 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16037384 |
| http://purl.uniprot.org/citations/16037384 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16037384 |
| http://purl.uniprot.org/uniprot/#_B2MUX6-mappedCitation-16037384 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16037384 |
| http://purl.uniprot.org/uniprot/#_E3UN46-mappedCitation-16037384 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16037384 |
| http://purl.uniprot.org/uniprot/#_P01344-mappedCitation-16037384 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16037384 |
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| http://purl.uniprot.org/uniprot/P09565 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16037384 |
| http://purl.uniprot.org/uniprot/P01344 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16037384 |
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