| http://purl.uniprot.org/citations/16039576 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16039576 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16039576 | http://www.w3.org/2000/01/rdf-schema#comment | "Toll-like receptors (TLRs) play an important role in antiviral response by recognizing viral components. Recently, a RNA helicase, RIG-I, was also suggested to recognize viral double-stranded RNA. However, how these molecules contribute to viral recognition in vivo is poorly understood. We show by gene targeting that RIG-I is essential for induction of type I interferons (IFNs) after infection with RNA viruses in fibroblasts and conventional dendritic cells (DCs). RIG-I induces type I IFNs by activating IRF3 via IkappaB kinase-related kinases. In contrast, plasmacytoid DCs, which produce large amounts of IFN-alpha, use the TLR system rather than RIG-I for viral detection. Taken together, RIG-I and the TLR system exert antiviral responses in a cell type-specific manner."xsd:string |
| http://purl.uniprot.org/citations/16039576 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2005.04.010"xsd:string |
| http://purl.uniprot.org/citations/16039576 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2005.04.010"xsd:string |
| http://purl.uniprot.org/citations/16039576 | http://purl.uniprot.org/core/author | "Kato H."xsd:string |
| http://purl.uniprot.org/citations/16039576 | http://purl.uniprot.org/core/author | "Kato H."xsd:string |
| http://purl.uniprot.org/citations/16039576 | http://purl.uniprot.org/core/author | "Matsui K."xsd:string |
| http://purl.uniprot.org/citations/16039576 | http://purl.uniprot.org/core/author | "Matsui K."xsd:string |
| http://purl.uniprot.org/citations/16039576 | http://purl.uniprot.org/core/author | "Fujita T."xsd:string |
| http://purl.uniprot.org/citations/16039576 | http://purl.uniprot.org/core/author | "Fujita T."xsd:string |
| http://purl.uniprot.org/citations/16039576 | http://purl.uniprot.org/core/author | "Sato S."xsd:string |
| http://purl.uniprot.org/citations/16039576 | http://purl.uniprot.org/core/author | "Sato S."xsd:string |
| http://purl.uniprot.org/citations/16039576 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/16039576 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/16039576 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/16039576 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/16039576 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/16039576 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/16039576 | http://purl.uniprot.org/core/author | "Tsujimura T."xsd:string |
| http://purl.uniprot.org/citations/16039576 | http://purl.uniprot.org/core/author | "Tsujimura T."xsd:string |
| http://purl.uniprot.org/citations/16039576 | http://purl.uniprot.org/core/author | "Takeuchi O."xsd:string |
| http://purl.uniprot.org/citations/16039576 | http://purl.uniprot.org/core/author | "Takeuchi O."xsd:string |
| http://purl.uniprot.org/citations/16039576 | http://purl.uniprot.org/core/author | "Yoneyama M."xsd:string |
| http://purl.uniprot.org/citations/16039576 | http://purl.uniprot.org/core/author | "Yoneyama M."xsd:string |