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http://purl.uniprot.org/citations/16042787http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16042787http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16042787http://www.w3.org/2000/01/rdf-schema#comment"

Background

Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia (ATL), whereas HTLV type 2 (HTLV-2), is not associated with ATL or any other leukemia. HTLV-1 encodes the transforming gene tax1, whose expression in an interleukin (IL)-2-dependent T-cell line (CTLL-2) induces IL-2-independent growth.

Results

In this study, we demonstrated that IL-2-independent growth induction by Tax1 was abrogated by mutations of the PDZ domain-binding motif (PBM) at the Tax1 C-terminus. HTLV-2 Tax2, which shares 75% amino acid identity with Tax1 but does not have a PBM, was not able to induce IL-2-independent growth of CTLL-2.

Conclusion

Our results suggest that Tax1, through interaction with PDZ domain protein(s) induces IL-2-independent growth, which may be a factor in multi-step leukemogenesis caused by HTLV-1."xsd:string
http://purl.uniprot.org/citations/16042787http://purl.org/dc/terms/identifier"doi:10.1186/1742-4690-2-46"xsd:string
http://purl.uniprot.org/citations/16042787http://purl.org/dc/terms/identifier"doi:10.1186/1742-4690-2-46"xsd:string
http://purl.uniprot.org/citations/16042787http://purl.uniprot.org/core/author"Fujii M."xsd:string
http://purl.uniprot.org/citations/16042787http://purl.uniprot.org/core/author"Fujii M."xsd:string
http://purl.uniprot.org/citations/16042787http://purl.uniprot.org/core/author"Tanaka Y."xsd:string
http://purl.uniprot.org/citations/16042787http://purl.uniprot.org/core/author"Tanaka Y."xsd:string
http://purl.uniprot.org/citations/16042787http://purl.uniprot.org/core/author"Takahashi M."xsd:string
http://purl.uniprot.org/citations/16042787http://purl.uniprot.org/core/author"Takahashi M."xsd:string
http://purl.uniprot.org/citations/16042787http://purl.uniprot.org/core/author"Higuchi M."xsd:string
http://purl.uniprot.org/citations/16042787http://purl.uniprot.org/core/author"Higuchi M."xsd:string
http://purl.uniprot.org/citations/16042787http://purl.uniprot.org/core/author"Gejyo F."xsd:string
http://purl.uniprot.org/citations/16042787http://purl.uniprot.org/core/author"Gejyo F."xsd:string
http://purl.uniprot.org/citations/16042787http://purl.uniprot.org/core/author"Oie M."xsd:string
http://purl.uniprot.org/citations/16042787http://purl.uniprot.org/core/author"Oie M."xsd:string
http://purl.uniprot.org/citations/16042787http://purl.uniprot.org/core/author"Tsubata C."xsd:string
http://purl.uniprot.org/citations/16042787http://purl.uniprot.org/core/author"Tsubata C."xsd:string
http://purl.uniprot.org/citations/16042787http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/16042787http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/16042787http://purl.uniprot.org/core/name"Retrovirology"xsd:string
http://purl.uniprot.org/citations/16042787http://purl.uniprot.org/core/name"Retrovirology"xsd:string
http://purl.uniprot.org/citations/16042787http://purl.uniprot.org/core/pages"46"xsd:string
http://purl.uniprot.org/citations/16042787http://purl.uniprot.org/core/pages"46"xsd:string
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