| http://purl.uniprot.org/citations/16043519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16043519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16043519 | http://www.w3.org/2000/01/rdf-schema#comment | "Identification of the T cell immunoglobulin mucin-domain containing (Tim) gene family introduced a new family of cell surface molecules that is involved in the regulation of immune responses. We previously demonstrated that Tim-3 is expressed on terminally differentiated T helper (Th)1 cells, and serves to regulate Th1 immune responses. Here, we describe the identification and function of Tim-2, a novel member of the Tim gene family. In contrast with Tim-3, we demonstrate that Tim-2 is expressed preferentially in differentiated Th2 cells. Blockade of the Tim-2/Tim-2 ligand interaction, by administration of soluble Tim-2 fusion protein (Tim-2 immunoglobulin [Ig]), results in T cell hyperproliferation and the production of Th2 cytokines. Administration of Tim-2 Ig during the induction phase reduces the severity of experimental autoimmune encephalomyelitis, a Th1-mediated autoimmune disease model of multiple sclerosis. We propose that Tim-2, an orthologue of human Tim-1, is critical for the regulation of Th2 responses during autoimmune inflammation."xsd:string |
| http://purl.uniprot.org/citations/16043519 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20050308"xsd:string |
| http://purl.uniprot.org/citations/16043519 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20050308"xsd:string |
| http://purl.uniprot.org/citations/16043519 | http://purl.uniprot.org/core/author | "Xiao S."xsd:string |
| http://purl.uniprot.org/citations/16043519 | http://purl.uniprot.org/core/author | "Xiao S."xsd:string |
| http://purl.uniprot.org/citations/16043519 | http://purl.uniprot.org/core/author | "Sabatos C.A."xsd:string |
| http://purl.uniprot.org/citations/16043519 | http://purl.uniprot.org/core/author | "Sabatos C.A."xsd:string |
| http://purl.uniprot.org/citations/16043519 | http://purl.uniprot.org/core/author | "Kuchroo V.K."xsd:string |
| http://purl.uniprot.org/citations/16043519 | http://purl.uniprot.org/core/author | "Kuchroo V.K."xsd:string |
| http://purl.uniprot.org/citations/16043519 | http://purl.uniprot.org/core/author | "Sobel R.A."xsd:string |
| http://purl.uniprot.org/citations/16043519 | http://purl.uniprot.org/core/author | "Sobel R.A."xsd:string |
| http://purl.uniprot.org/citations/16043519 | http://purl.uniprot.org/core/author | "Chakravarti S."xsd:string |
| http://purl.uniprot.org/citations/16043519 | http://purl.uniprot.org/core/author | "Chakravarti S."xsd:string |
| http://purl.uniprot.org/citations/16043519 | http://purl.uniprot.org/core/author | "Illes Z."xsd:string |
| http://purl.uniprot.org/citations/16043519 | http://purl.uniprot.org/core/author | "Illes Z."xsd:string |
| http://purl.uniprot.org/citations/16043519 | http://purl.uniprot.org/core/author | "Strom T.B."xsd:string |
| http://purl.uniprot.org/citations/16043519 | http://purl.uniprot.org/core/author | "Strom T.B."xsd:string |
| http://purl.uniprot.org/citations/16043519 | http://purl.uniprot.org/core/author | "Zheng X.X."xsd:string |
| http://purl.uniprot.org/citations/16043519 | http://purl.uniprot.org/core/author | "Zheng X.X."xsd:string |
| http://purl.uniprot.org/citations/16043519 | http://purl.uniprot.org/core/author | "Cha E.K."xsd:string |
| http://purl.uniprot.org/citations/16043519 | http://purl.uniprot.org/core/author | "Cha E.K."xsd:string |
| http://purl.uniprot.org/citations/16043519 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16043519 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |