| http://purl.uniprot.org/citations/16044003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16044003 | http://www.w3.org/2000/01/rdf-schema#comment | "The factors that determine the emergence of X4 isolates in some HIV-1-infected subjects are unknown. As the level of expression of CXCR4 could favor an R5 to X4 switch, quantitative flow cytometry was used to measure CXCR4 density on CD4 T cells in 200 HIV-1-positive adults, and this was compared with CD4 counts, interleukin-7 (IL-7), and RANTES (regulated on activation, normal T expressed and secreted) plasma levels and the R5/X4 virus phenotype. CD4 T-cell surface CXCR4 densities were increased in infected subjects and inversely correlated with CD4 T-cell count (r=-0.548, P<0.001). Yet, in vitro infection with either R5 or X4 strains and in vivo increases in viral load following interruption of antiretroviral treatment did not induce CXCR4 overexpression. The plasma levels of IL-7 and RANTES, 2 cytokines able to induce CXCR4 expression, did not correlate with CXCR4 density. Finally, higher CXCR4 densities were observed in patients harboring X4 strains (3300, 95% CI 2431-4169 CXCR4 molecules per cell) than in patients harboring only R5 strains (2406, 95% CI 2135-2677, P=0.027). These data suggest that CXCR4 overexpression during the course of the disease in some patients could favor the emergence of X4 strains."xsd:string |
| http://purl.uniprot.org/citations/16044003 | http://purl.uniprot.org/core/author | "Lin Y.L."xsd:string |
| http://purl.uniprot.org/citations/16044003 | http://purl.uniprot.org/core/author | "Reynes J."xsd:string |
| http://purl.uniprot.org/citations/16044003 | http://purl.uniprot.org/core/author | "Portales P."xsd:string |
| http://purl.uniprot.org/citations/16044003 | http://purl.uniprot.org/core/author | "Clot J."xsd:string |
| http://purl.uniprot.org/citations/16044003 | http://purl.uniprot.org/core/author | "Segondy M."xsd:string |
| http://purl.uniprot.org/citations/16044003 | http://purl.uniprot.org/core/author | "Montes B."xsd:string |
| http://purl.uniprot.org/citations/16044003 | http://purl.uniprot.org/core/author | "Corbeau P."xsd:string |
| http://purl.uniprot.org/citations/16044003 | http://purl.uniprot.org/core/author | "Baillat V."xsd:string |
| http://purl.uniprot.org/citations/16044003 | http://purl.uniprot.org/core/author | "Le Moing V."xsd:string |
| http://purl.uniprot.org/citations/16044003 | http://purl.uniprot.org/core/author | "Reant B."xsd:string |
| http://purl.uniprot.org/citations/16044003 | http://purl.uniprot.org/core/author | "de Boever C.M."xsd:string |
| http://purl.uniprot.org/citations/16044003 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16044003 | http://purl.uniprot.org/core/name | "J Acquir Immune Defic Syndr"xsd:string |
| http://purl.uniprot.org/citations/16044003 | http://purl.uniprot.org/core/pages | "530-536"xsd:string |
| http://purl.uniprot.org/citations/16044003 | http://purl.uniprot.org/core/title | "CXCR4 overexpression during the course of HIV-1 infection correlates with the emergence of X4 strains."xsd:string |
| http://purl.uniprot.org/citations/16044003 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/16044003 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16044003 |
| http://purl.uniprot.org/citations/16044003 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16044003 |
| http://purl.uniprot.org/uniprot/#_A0A0U3FJG0-mappedCitation-16044003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16044003 |
| http://purl.uniprot.org/uniprot/#_A0A0U3GXA9-mappedCitation-16044003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16044003 |
| http://purl.uniprot.org/uniprot/#_A0A8Q3WLL1-mappedCitation-16044003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16044003 |
| http://purl.uniprot.org/uniprot/#_P61073-mappedCitation-16044003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16044003 |
| http://purl.uniprot.org/uniprot/#_Q5MIL4-mappedCitation-16044003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16044003 |