| http://purl.uniprot.org/citations/16046410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16046410 | http://www.w3.org/2000/01/rdf-schema#comment | "Apoptosis of pancreatic beta cells is implicated in the onset of type 1 and type 2 diabetes. Consequently, strategies aimed at increasing the resistance of beta cells toward apoptosis could be beneficial in the treatment of diabetes. RasGAP, a regulator of Ras and Rho GTPases, is an atypical caspase substrate, since it inhibits, rather than favors, apoptosis when it is partially cleaved by caspase-3 at position 455. The antiapoptotic signal generated by the partial processing of RasGAP is mediated by the N-terminal fragment (fragment N) in a Ras-phosphatidylinositol 3-kinase-Akt-dependent, but NF-kappaB-independent, manner. Further cleavage of fragment N at position 157 abrogates its antiapoptotic properties. Here we demonstrate that an uncleavable form of fragment N activates Akt, represses NF-kappaB activity, and protects the conditionally immortalized pancreatic insulinoma betaTC-tet cell line against various insults, including exposure to genotoxins, trophic support withdrawal, and incubation with inflammatory cytokines. Fragment N also induced Akt activity and protection against cytokine-induced apoptosis in primary pancreatic islet cells. Fragment N did not alter insulin cell content and insulin secretion in response to glucose. These data indicate that fragment N protects beta cells without affecting their function. The pathways regulated by fragment N are therefore promising targets for antidiabetogenic therapy."xsd:string |
| http://purl.uniprot.org/citations/16046410 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m504058200"xsd:string |
| http://purl.uniprot.org/citations/16046410 | http://purl.uniprot.org/core/author | "Yang J.Y."xsd:string |
| http://purl.uniprot.org/citations/16046410 | http://purl.uniprot.org/core/author | "Abderrahmani A."xsd:string |
| http://purl.uniprot.org/citations/16046410 | http://purl.uniprot.org/core/author | "Waeber G."xsd:string |
| http://purl.uniprot.org/citations/16046410 | http://purl.uniprot.org/core/author | "Widmann C."xsd:string |
| http://purl.uniprot.org/citations/16046410 | http://purl.uniprot.org/core/author | "Thorens B."xsd:string |
| http://purl.uniprot.org/citations/16046410 | http://purl.uniprot.org/core/author | "Cornu M."xsd:string |
| http://purl.uniprot.org/citations/16046410 | http://purl.uniprot.org/core/author | "Walicki J."xsd:string |
| http://purl.uniprot.org/citations/16046410 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16046410 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/16046410 | http://purl.uniprot.org/core/pages | "32835-32842"xsd:string |
| http://purl.uniprot.org/citations/16046410 | http://purl.uniprot.org/core/title | "Expression of an uncleavable N-terminal RasGAP fragment in insulin-secreting cells increases their resistance toward apoptotic stimuli without affecting their glucose-induced insulin secretion."xsd:string |
| http://purl.uniprot.org/citations/16046410 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/16046410 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16046410 |
| http://purl.uniprot.org/citations/16046410 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16046410 |
| http://purl.uniprot.org/uniprot/#_A3KMH3-mappedCitation-16046410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16046410 |
| http://purl.uniprot.org/uniprot/#_A6I4L9-mappedCitation-16046410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16046410 |
| http://purl.uniprot.org/uniprot/#_A6I4M0-mappedCitation-16046410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16046410 |
| http://purl.uniprot.org/uniprot/#_A6I4M1-mappedCitation-16046410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16046410 |
| http://purl.uniprot.org/uniprot/#_B4DTX4-mappedCitation-16046410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16046410 |
| http://purl.uniprot.org/uniprot/#_B4DTL8-mappedCitation-16046410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16046410 |
| http://purl.uniprot.org/uniprot/#_E9PYG6-mappedCitation-16046410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16046410 |
| http://purl.uniprot.org/uniprot/#_Q3V090-mappedCitation-16046410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16046410 |