| http://purl.uniprot.org/citations/16046553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16046553 | http://www.w3.org/2000/01/rdf-schema#comment | "Leukotrienes (LT) and prostaglandins (PG) are proinflammatory mediators generated by the conversion of arachidonic acid via 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways. It has long been proposed that the inhibition of the 5-LO could enhance the COX pathway leading to an increased PG generation. We have found that in in vitro models of inflammation, such as mice-elicited peritoneal macrophages activated with lipopolysaccharide (LPS)/interferon-gamma (IFN-gamma), the deletion of the gene encoding for 5-LO or the enzyme activity inhibition corresponded to a negative modulation of the COX pathway. Moreover, exogenously added LTC(4), but not LTD(4), LTE(4), and LTB(4), was able to increase PG production in stimulated cells from 5-LO wild-type and knockout mice. LTC(4) was not able to induce COX-2 expression by itself but rather potentiated the action of LPS/IFN-gamma through the extracellular signal-regulated kinase-1/2 activation, as demonstrated by the use of a specific mitogen-activated protein kinase (MAPK) kinase inhibitor. The LT-induced increase in PG generation, as well as MAPK activation, was dependent by a specific ligand-receptor interaction, as demonstrated by the use of a cys-LT1 receptor antagonist, although also a direct action of the antagonist used, on PG generation, cannot be excluded. Thus, the balance between COX and 5-LO metabolites could be of great importance in controlling macrophage functions and consequently, inflammation and tumor promotion."xsd:string |
| http://purl.uniprot.org/citations/16046553 | http://purl.org/dc/terms/identifier | "doi:10.1189/jlb.1004619"xsd:string |
| http://purl.uniprot.org/citations/16046553 | http://purl.uniprot.org/core/author | "Rossi A."xsd:string |
| http://purl.uniprot.org/citations/16046553 | http://purl.uniprot.org/core/author | "Di Paola R."xsd:string |
| http://purl.uniprot.org/citations/16046553 | http://purl.uniprot.org/core/author | "Acquaviva A.M."xsd:string |
| http://purl.uniprot.org/citations/16046553 | http://purl.uniprot.org/core/author | "Cuzzocrea S."xsd:string |
| http://purl.uniprot.org/citations/16046553 | http://purl.uniprot.org/core/author | "Sautebin L."xsd:string |
| http://purl.uniprot.org/citations/16046553 | http://purl.uniprot.org/core/author | "Iuliano F."xsd:string |
| http://purl.uniprot.org/citations/16046553 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16046553 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/16046553 | http://purl.uniprot.org/core/pages | "985-991"xsd:string |
| http://purl.uniprot.org/citations/16046553 | http://purl.uniprot.org/core/title | "Up-regulation of prostaglandin biosynthesis by leukotriene C4 in elicited mice peritoneal macrophages activated with lipopolysaccharide/interferon-{gamma}."xsd:string |
| http://purl.uniprot.org/citations/16046553 | http://purl.uniprot.org/core/volume | "78"xsd:string |
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