| http://purl.uniprot.org/citations/16049345 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16049345 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16049345 | http://www.w3.org/2000/01/rdf-schema#comment | "Allograft inflammatory factor (AIF)-1 is a cytoplasmic, calcium-binding protein whose expression in transplanted human hearts correlates with rejection and development of coronary artery vasculopathy (CAV). AIF-1 is constitutively expressed in monocytes/macrophages, but its expression in human lymphocytes has not been described. After immunohistochemical analysis of human coronary arteries with CAV, we identified AIF-1 expression in CD3-positive lymphocytes. AIF-1 was differentially expressed in peripheral blood mononuclear cells and in the T-lymphoblastoid MOLT-4 cell line exposed to various cytokines, suggesting a role for AIF-1 in T-lymphocyte activation. To determine AIF-1 function, MOLT-4 cells were stably transduced by AIF-1 retrovirus. Overexpression of AIF-1 in these cells led to a 238% increase in cell number compared to empty vector controls. AIF-1 polymerized nonmuscle actin and MOLT-4 cells overexpressing AIF-1 migrated 95% more rapidly than empty vector controls. Primary human vascular smooth muscle cells cultured in conditioned media from AIF-1-transduced MOLT-4 cells proliferated 99% more rapidly than vascular smooth muscle cells cultured in conditioned media from empty vector-transduced MOLT-4 cells. These data indicate that AIF-1 is expressed in activated T lymphocytes, that its expression enhances activation of lymphocytes, and that AIF-1 expression in activated lymphocytes may have important ramifications for activation of adjacent arterial vascular smooth muscle cells and development of CAV."xsd:string |
| http://purl.uniprot.org/citations/16049345 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0002-9440(10)63003-9"xsd:string |
| http://purl.uniprot.org/citations/16049345 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0002-9440(10)63003-9"xsd:string |
| http://purl.uniprot.org/citations/16049345 | http://purl.uniprot.org/core/author | "Autieri M.V."xsd:string |
| http://purl.uniprot.org/citations/16049345 | http://purl.uniprot.org/core/author | "Autieri M.V."xsd:string |
| http://purl.uniprot.org/citations/16049345 | http://purl.uniprot.org/core/author | "Kelemen S.E."xsd:string |
| http://purl.uniprot.org/citations/16049345 | http://purl.uniprot.org/core/author | "Kelemen S.E."xsd:string |
| http://purl.uniprot.org/citations/16049345 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16049345 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16049345 | http://purl.uniprot.org/core/name | "Am. J. Pathol."xsd:string |
| http://purl.uniprot.org/citations/16049345 | http://purl.uniprot.org/core/name | "Am. J. Pathol."xsd:string |
| http://purl.uniprot.org/citations/16049345 | http://purl.uniprot.org/core/pages | "619-626"xsd:string |
| http://purl.uniprot.org/citations/16049345 | http://purl.uniprot.org/core/pages | "619-626"xsd:string |
| http://purl.uniprot.org/citations/16049345 | http://purl.uniprot.org/core/title | "Expression of allograft inflammatory factor-1 in T lymphocytes: a role in T-lymphocyte activation and proliferative arteriopathies."xsd:string |
| http://purl.uniprot.org/citations/16049345 | http://purl.uniprot.org/core/title | "Expression of allograft inflammatory factor-1 in T lymphocytes: a role in T-lymphocyte activation and proliferative arteriopathies."xsd:string |
| http://purl.uniprot.org/citations/16049345 | http://purl.uniprot.org/core/volume | "167"xsd:string |
| http://purl.uniprot.org/citations/16049345 | http://purl.uniprot.org/core/volume | "167"xsd:string |
| http://purl.uniprot.org/citations/16049345 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16049345 |
| http://purl.uniprot.org/citations/16049345 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16049345 |
| http://purl.uniprot.org/citations/16049345 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16049345 |
| http://purl.uniprot.org/citations/16049345 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16049345 |
| http://purl.uniprot.org/uniprot/P55008 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/16049345 |
| http://purl.uniprot.org/uniprot/P55008#attribution-9EBCFF58B61B40393319F700ADB51B8D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16049345 |