| http://purl.uniprot.org/citations/16049479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16049479 | http://www.w3.org/2000/01/rdf-schema#comment | "Chemical synapses are complex structures that mediate rapid intercellular signalling in the nervous system. Proteomic studies suggest that several hundred proteins will be found at synaptic specializations. Here we describe a systematic screen to identify genes required for the function or development of Caenorhabditis elegans neuromuscular junctions. A total of 185 genes were identified in an RNA interference screen for decreased acetylcholine secretion; 132 of these genes had not previously been implicated in synaptic transmission. Functional profiles for these genes were determined by comparing secretion defects observed after RNA interference under a variety of conditions. Hierarchical clustering identified groups of functionally related genes, including those involved in the synaptic vesicle cycle, neuropeptide signalling and responsiveness to phorbol esters. Twenty-four genes encoded proteins that were localized to presynaptic specializations. Loss-of-function mutations in 12 genes caused defects in presynaptic structure."xsd:string |
| http://purl.uniprot.org/citations/16049479 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature03809"xsd:string |
| http://purl.uniprot.org/citations/16049479 | http://purl.uniprot.org/core/author | "Kennedy S."xsd:string |
| http://purl.uniprot.org/citations/16049479 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/16049479 | http://purl.uniprot.org/core/author | "Vidal M."xsd:string |
| http://purl.uniprot.org/citations/16049479 | http://purl.uniprot.org/core/author | "Hill D.E."xsd:string |
| http://purl.uniprot.org/citations/16049479 | http://purl.uniprot.org/core/author | "Kaplan J.M."xsd:string |
| http://purl.uniprot.org/citations/16049479 | http://purl.uniprot.org/core/author | "Sieburth D."xsd:string |
| http://purl.uniprot.org/citations/16049479 | http://purl.uniprot.org/core/author | "Ruvkun G."xsd:string |
| http://purl.uniprot.org/citations/16049479 | http://purl.uniprot.org/core/author | "Dybbs M."xsd:string |
| http://purl.uniprot.org/citations/16049479 | http://purl.uniprot.org/core/author | "Rual J.F."xsd:string |
| http://purl.uniprot.org/citations/16049479 | http://purl.uniprot.org/core/author | "Ch'ng Q."xsd:string |
| http://purl.uniprot.org/citations/16049479 | http://purl.uniprot.org/core/author | "Dupuy D."xsd:string |
| http://purl.uniprot.org/citations/16049479 | http://purl.uniprot.org/core/author | "Tavazoie M."xsd:string |
| http://purl.uniprot.org/citations/16049479 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16049479 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/16049479 | http://purl.uniprot.org/core/pages | "510-517"xsd:string |
| http://purl.uniprot.org/citations/16049479 | http://purl.uniprot.org/core/title | "Systematic analysis of genes required for synapse structure and function."xsd:string |
| http://purl.uniprot.org/citations/16049479 | http://purl.uniprot.org/core/volume | "436"xsd:string |
| http://purl.uniprot.org/citations/16049479 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16049479 |
| http://purl.uniprot.org/citations/16049479 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16049479 |
| http://purl.uniprot.org/uniprot/G5EGI2#attribution-3ADCB6BC0DC3E8212CDE5B0A27DA3809 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16049479 |
| http://purl.uniprot.org/uniprot/G5EGI2#attribution-67B68921ED6A09B4F315049FEFEEA370 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16049479 |
| http://purl.uniprot.org/uniprot/Q8MXU3#attribution-3ADCB6BC0DC3E8212CDE5B0A27DA3809 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16049479 |