| http://purl.uniprot.org/citations/16051149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16051149 | http://www.w3.org/2000/01/rdf-schema#comment | "T cells bearing alphabeta T cell receptors (TCRs) recognize antigens in the form of peptides bound to class I or class II major histocompatibility proteins (MHC). TCRs on mature T cells are usually very specific for both peptide and MHC class and allele. They are picked out from a precursor population in the thymus by MHC-driven positive and negative selection. Here we show that the pool of T cells initially positively selected in the thymus contains many T cells that are very crossreactive for peptide and MHC and that subsequent negative selection establishes the MHC-restriction and peptide specificity of peripheral T cells. Our results also suggest that germline-encoded TCR variable elements have an inherent predisposition to react with features shared by all MHC proteins."xsd:string |
| http://purl.uniprot.org/citations/16051149 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2005.05.013"xsd:string |
| http://purl.uniprot.org/citations/16051149 | http://purl.uniprot.org/core/author | "Becker D."xsd:string |
| http://purl.uniprot.org/citations/16051149 | http://purl.uniprot.org/core/author | "White J."xsd:string |
| http://purl.uniprot.org/citations/16051149 | http://purl.uniprot.org/core/author | "Crawford F."xsd:string |
| http://purl.uniprot.org/citations/16051149 | http://purl.uniprot.org/core/author | "Kappler J.W."xsd:string |
| http://purl.uniprot.org/citations/16051149 | http://purl.uniprot.org/core/author | "Marrack P."xsd:string |
| http://purl.uniprot.org/citations/16051149 | http://purl.uniprot.org/core/author | "Vass T."xsd:string |
| http://purl.uniprot.org/citations/16051149 | http://purl.uniprot.org/core/author | "Huseby E.S."xsd:string |
| http://purl.uniprot.org/citations/16051149 | http://purl.uniprot.org/core/author | "Pinilla C."xsd:string |
| http://purl.uniprot.org/citations/16051149 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16051149 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/16051149 | http://purl.uniprot.org/core/pages | "247-260"xsd:string |
| http://purl.uniprot.org/citations/16051149 | http://purl.uniprot.org/core/title | "How the T cell repertoire becomes peptide and MHC specific."xsd:string |
| http://purl.uniprot.org/citations/16051149 | http://purl.uniprot.org/core/volume | "122"xsd:string |
| http://purl.uniprot.org/citations/16051149 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16051149 |
| http://purl.uniprot.org/citations/16051149 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16051149 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B3-mappedCitation-16051149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16051149 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G5-mappedCitation-16051149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16051149 |
| http://purl.uniprot.org/uniprot/#_A0A494B9U2-mappedCitation-16051149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16051149 |
| http://purl.uniprot.org/uniprot/#_P06342-mappedCitation-16051149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16051149 |
| http://purl.uniprot.org/uniprot/#_P06343-mappedCitation-16051149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16051149 |
| http://purl.uniprot.org/uniprot/#_P06345-mappedCitation-16051149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16051149 |
| http://purl.uniprot.org/uniprot/#_P06346-mappedCitation-16051149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16051149 |