| http://purl.uniprot.org/citations/16051830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16051830 | http://www.w3.org/2000/01/rdf-schema#comment | "Alpha/beta interferons (IFN-alpha/beta) are key mediators of innate immunity and important modulators of adaptive immunity. The mechanisms by which IFN-alpha/beta are induced are becoming increasingly well understood. Recent studies showed that Toll-like receptors 7 and 8 expressed by plasmacytoid dendritic cells (pDCs) mediate the endosomal recognition of incoming viral RNA genomes, a process which requires myeloid differentiation factor 88 (MyD88). Here we investigate the requirements for virus-induced IFN-alpha/beta production in cultures of bone marrow-derived murine myeloid DCs (mDCs). Using recombinant Semliki Forest virus blocked at different steps in the viral life cycle, we show that replication-defective virus induced IFN-alpha/beta in mDCs while fusion-defective virus did not induce IFN-alpha/beta. The response to replication-defective virus was largely intact in MyD88-/-mDC cultures but was severely reduced in mDC cultures from mice lacking IFN regulatory factor 3. Our observations suggest that mDCs respond to incoming virus via a pathway that differs from the fusion-independent, MyD88-mediated endosomal pathway described for the induction of IFN-alpha/beta in pDCs. We propose that events during or downstream of viral fusion, but prior to replication, can activate IFN-alpha/beta in mDCs. Thus, mDCs may contribute to the antiviral response activated by the immune system at early time points after infection."xsd:string |
| http://purl.uniprot.org/citations/16051830 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.79.16.10376-10385.2005"xsd:string |
| http://purl.uniprot.org/citations/16051830 | http://purl.uniprot.org/core/author | "Werner K.M."xsd:string |
| http://purl.uniprot.org/citations/16051830 | http://purl.uniprot.org/core/author | "McInerney G.M."xsd:string |
| http://purl.uniprot.org/citations/16051830 | http://purl.uniprot.org/core/author | "Karlsson Hedestam G.B."xsd:string |
| http://purl.uniprot.org/citations/16051830 | http://purl.uniprot.org/core/author | "Liljestrom P."xsd:string |
| http://purl.uniprot.org/citations/16051830 | http://purl.uniprot.org/core/author | "Douagi I."xsd:string |
| http://purl.uniprot.org/citations/16051830 | http://purl.uniprot.org/core/author | "Hidmark A.S."xsd:string |
| http://purl.uniprot.org/citations/16051830 | http://purl.uniprot.org/core/author | "Nordstrom E.K."xsd:string |
| http://purl.uniprot.org/citations/16051830 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16051830 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/16051830 | http://purl.uniprot.org/core/pages | "10376-10385"xsd:string |
| http://purl.uniprot.org/citations/16051830 | http://purl.uniprot.org/core/title | "Early alpha/beta interferon production by myeloid dendritic cells in response to UV-inactivated virus requires viral entry and interferon regulatory factor 3 but not MyD88."xsd:string |
| http://purl.uniprot.org/citations/16051830 | http://purl.uniprot.org/core/volume | "79"xsd:string |
| http://purl.uniprot.org/citations/16051830 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16051830 |
| http://purl.uniprot.org/citations/16051830 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16051830 |
| http://purl.uniprot.org/uniprot/#_P70671-mappedCitation-16051830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16051830 |
| http://purl.uniprot.org/uniprot/#_A0A140LHE6-mappedCitation-16051830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16051830 |
| http://purl.uniprot.org/uniprot/#_A0A140LI96-mappedCitation-16051830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16051830 |
| http://purl.uniprot.org/uniprot/#_A0A140LJD9-mappedCitation-16051830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16051830 |
| http://purl.uniprot.org/uniprot/#_A0A140LJE8-mappedCitation-16051830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16051830 |
| http://purl.uniprot.org/uniprot/#_C0IXK2-mappedCitation-16051830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16051830 |
| http://purl.uniprot.org/uniprot/#_Q3U9K6-mappedCitation-16051830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16051830 |
| http://purl.uniprot.org/uniprot/#_Q3UJM9-mappedCitation-16051830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16051830 |