| http://purl.uniprot.org/citations/16051867 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16051867 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16051867 | http://www.w3.org/2000/01/rdf-schema#comment | "The myxoma virus (MV) M-T5 gene encodes an ankyrin repeat protein that is important for virus replication in cells from several species. Insight was gained into the molecular mechanisms underlying the role of M-T5 as a host range determinant when the cell cycle regulatory protein cullin-1 (cul-1) was identified as a cellular binding partner of M-T5 and found to colocalize with the protein in both nuclear and cytosolic compartments. Consistent with this interaction, infection with wild-type MV (vMyxlac) or a deletion mutant lacking M-T5 (vMyxT5KO) differentially altered cell cycle progression in a panel of permissive and nonpermissive cells. Cells infected with vMyxlac transitioned rapidly out of the G0/G1 phase and preferentially accumulated at the G2/M checkpoint, whereas infection with vMyxT5KO impeded progression through the cell cycle, resulting in a greater percentage of cells retained at G0/G1. Levels of the cul-1 substrate, p27/Kip-1, were selectively increased in cells infected with vMyxT5KO compared to vMyxlac, concurrent with decreased phosphorylation of p27/Kip-1 at Thr187 and decreased ubiquitination. Compared to cells infected with vMyxlac, cell death was increased in vMyxT5KO-infected cells following treatment with diverse stimuli known to induce cell cycle arrest, including infection itself, serum deprivation, and exposure to proteasome inhibitors or double-stranded RNA. Moreover, infection with vMyxlac, but not vMyxT5KO, was sufficient to overcome the G0/G1 arrest induced by these stimuli. These findings suggest that M-T5 regulates cell cycle progression at the G0/G1 checkpoint, thereby protecting infected cells from diverse innate host antiviral responses normally triggered by G0/G1 cell cycle arrest."xsd:string |
| http://purl.uniprot.org/citations/16051867 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.79.16.10750-10763.2005"xsd:string |
| http://purl.uniprot.org/citations/16051867 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.79.16.10750-10763.2005"xsd:string |
| http://purl.uniprot.org/citations/16051867 | http://purl.uniprot.org/core/author | "Barrett J.W."xsd:string |
| http://purl.uniprot.org/citations/16051867 | http://purl.uniprot.org/core/author | "Barrett J.W."xsd:string |
| http://purl.uniprot.org/citations/16051867 | http://purl.uniprot.org/core/author | "McFadden G."xsd:string |
| http://purl.uniprot.org/citations/16051867 | http://purl.uniprot.org/core/author | "McFadden G."xsd:string |
| http://purl.uniprot.org/citations/16051867 | http://purl.uniprot.org/core/author | "Wang G."xsd:string |
| http://purl.uniprot.org/citations/16051867 | http://purl.uniprot.org/core/author | "Wang G."xsd:string |
| http://purl.uniprot.org/citations/16051867 | http://purl.uniprot.org/core/author | "Colwill K."xsd:string |
| http://purl.uniprot.org/citations/16051867 | http://purl.uniprot.org/core/author | "Colwill K."xsd:string |
| http://purl.uniprot.org/citations/16051867 | http://purl.uniprot.org/core/author | "Johnston J.B."xsd:string |
| http://purl.uniprot.org/citations/16051867 | http://purl.uniprot.org/core/author | "Johnston J.B."xsd:string |
| http://purl.uniprot.org/citations/16051867 | http://purl.uniprot.org/core/author | "Nazarian S.H."xsd:string |
| http://purl.uniprot.org/citations/16051867 | http://purl.uniprot.org/core/author | "Nazarian S.H."xsd:string |
| http://purl.uniprot.org/citations/16051867 | http://purl.uniprot.org/core/author | "Moran M."xsd:string |
| http://purl.uniprot.org/citations/16051867 | http://purl.uniprot.org/core/author | "Moran M."xsd:string |
| http://purl.uniprot.org/citations/16051867 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16051867 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16051867 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/16051867 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/16051867 | http://purl.uniprot.org/core/pages | "10750-10763"xsd:string |
| http://purl.uniprot.org/citations/16051867 | http://purl.uniprot.org/core/pages | "10750-10763"xsd:string |