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http://purl.uniprot.org/citations/16054033http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16054033http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16054033http://www.w3.org/2000/01/rdf-schema#comment"The insulin/PI3K signaling pathway controls both tissue growth and metabolism. Here, we identify Melted as a new modulator of this pathway in Drosophila. Melted interacts with both Tsc1 and FOXO and can recruit these proteins to the cell membrane. We provide evidence that in the melted mutant, TOR activity is reduced and FOXO is activated. The melted mutant condition mimics the effects of nutrient deprivation in a normal animal, producing an animal with 40% less fat than normal."xsd:string
http://purl.uniprot.org/citations/16054033http://purl.org/dc/terms/identifier"doi:10.1016/j.devcel.2005.07.004"xsd:string
http://purl.uniprot.org/citations/16054033http://purl.org/dc/terms/identifier"doi:10.1016/j.devcel.2005.07.004"xsd:string
http://purl.uniprot.org/citations/16054033http://purl.uniprot.org/core/author"Teleman A.A."xsd:string
http://purl.uniprot.org/citations/16054033http://purl.uniprot.org/core/author"Teleman A.A."xsd:string
http://purl.uniprot.org/citations/16054033http://purl.uniprot.org/core/author"Cohen S.M."xsd:string
http://purl.uniprot.org/citations/16054033http://purl.uniprot.org/core/author"Cohen S.M."xsd:string
http://purl.uniprot.org/citations/16054033http://purl.uniprot.org/core/author"Chen Y.-W."xsd:string
http://purl.uniprot.org/citations/16054033http://purl.uniprot.org/core/author"Chen Y.-W."xsd:string
http://purl.uniprot.org/citations/16054033http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/16054033http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/16054033http://purl.uniprot.org/core/name"Dev. Cell"xsd:string
http://purl.uniprot.org/citations/16054033http://purl.uniprot.org/core/name"Dev. Cell"xsd:string
http://purl.uniprot.org/citations/16054033http://purl.uniprot.org/core/pages"271-281"xsd:string
http://purl.uniprot.org/citations/16054033http://purl.uniprot.org/core/pages"271-281"xsd:string
http://purl.uniprot.org/citations/16054033http://purl.uniprot.org/core/title"Drosophila Melted modulates FOXO and TOR activity."xsd:string
http://purl.uniprot.org/citations/16054033http://purl.uniprot.org/core/title"Drosophila Melted modulates FOXO and TOR activity."xsd:string
http://purl.uniprot.org/citations/16054033http://purl.uniprot.org/core/volume"9"xsd:string
http://purl.uniprot.org/citations/16054033http://purl.uniprot.org/core/volume"9"xsd:string
http://purl.uniprot.org/citations/16054033http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16054033
http://purl.uniprot.org/citations/16054033http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16054033
http://purl.uniprot.org/citations/16054033http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16054033
http://purl.uniprot.org/citations/16054033http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16054033