| http://purl.uniprot.org/citations/16054130 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16054130 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16054130 | http://www.w3.org/2000/01/rdf-schema#comment | "We recently described that in the metastasizing rat pancreatic carcinoma line BSp73ASML the cell-cell adhesion molecule EpCAM, CD44 variant isoforms and the tetraspanins D6.1A and CD9 form a complex that is located in glycolipid-enriched membrane microdomains. This complex contains, in addition, an undefined 20 kDa protein. As such complex formation influenced cell-cell adhesion and apoptosis resistance, it became of interest to identify the 20 kDa polypeptide. This 20 kDa protein, which co-precipitated with EpCAM in BSp73ASML lysates, was identified as the tight junction protein claudin-7. Correspondingly, an association between EpCAM and claudin-7 was noted in rat and human tumors and in non-transformed tissues of the gastrointestinal tract. Co-localization of the two molecules was most pronounced at basolateral membranes, but was also observed in tight junctions. Evidence for direct protein-protein interactions between EpCAM and claudin-7 was obtained by co-immunoprecipitation after treatment of tumor cells with a membrane-permeable chemical cross-linker. The complex, which is located in glycolipid-enriched membrane microdomains, is not disrupted by partial cholesterol depletion, but claudin-7 phosphorylation is restricted to the localization in glycolipid-enriched membrane microdomains. This is the first report on an association between EpCAM and claudins in both non-transformed tissues and metastasizing tumor cell lines."xsd:string |
| http://purl.uniprot.org/citations/16054130 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2005.06.013"xsd:string |
| http://purl.uniprot.org/citations/16054130 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2005.06.013"xsd:string |
| http://purl.uniprot.org/citations/16054130 | http://purl.uniprot.org/core/author | "Fiedler S."xsd:string |
| http://purl.uniprot.org/citations/16054130 | http://purl.uniprot.org/core/author | "Fiedler S."xsd:string |
| http://purl.uniprot.org/citations/16054130 | http://purl.uniprot.org/core/author | "Langbein L."xsd:string |
| http://purl.uniprot.org/citations/16054130 | http://purl.uniprot.org/core/author | "Langbein L."xsd:string |
| http://purl.uniprot.org/citations/16054130 | http://purl.uniprot.org/core/author | "Schnoelzer M."xsd:string |
| http://purl.uniprot.org/citations/16054130 | http://purl.uniprot.org/core/author | "Schnoelzer M."xsd:string |
| http://purl.uniprot.org/citations/16054130 | http://purl.uniprot.org/core/author | "Franke W.W."xsd:string |
| http://purl.uniprot.org/citations/16054130 | http://purl.uniprot.org/core/author | "Franke W.W."xsd:string |
| http://purl.uniprot.org/citations/16054130 | http://purl.uniprot.org/core/author | "Zoeller M."xsd:string |
| http://purl.uniprot.org/citations/16054130 | http://purl.uniprot.org/core/author | "Zoeller M."xsd:string |
| http://purl.uniprot.org/citations/16054130 | http://purl.uniprot.org/core/author | "Ladwein M."xsd:string |
| http://purl.uniprot.org/citations/16054130 | http://purl.uniprot.org/core/author | "Ladwein M."xsd:string |
| http://purl.uniprot.org/citations/16054130 | http://purl.uniprot.org/core/author | "Moldenhauer G."xsd:string |
| http://purl.uniprot.org/citations/16054130 | http://purl.uniprot.org/core/author | "Moldenhauer G."xsd:string |
| http://purl.uniprot.org/citations/16054130 | http://purl.uniprot.org/core/author | "Pape U.F."xsd:string |
| http://purl.uniprot.org/citations/16054130 | http://purl.uniprot.org/core/author | "Pape U.F."xsd:string |
| http://purl.uniprot.org/citations/16054130 | http://purl.uniprot.org/core/author | "Schmidt D.S."xsd:string |
| http://purl.uniprot.org/citations/16054130 | http://purl.uniprot.org/core/author | "Schmidt D.S."xsd:string |
| http://purl.uniprot.org/citations/16054130 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16054130 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |