| http://purl.uniprot.org/citations/16054612 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16054612 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously showed that the known HLA-B27-restricted influenza A epitope identified from human studies, NP.383-391, was recognized by CTLs following influenza A infection of transgenic (Tg) HLA-B27/H2 class I-deficient (H2 DKO) mice. Here, we examined the kinetics of the primary NP.383-391-specific response in Tg HLA-B27/H2 DKO mice at the site of respiratory infection, along with the profile of additional influenza A epitopes recognized. While the temporal kinetics of the Tg HLA-B27/NP.383-391-specific CD8+ T cell response paralleled the H2-D(b)/NP.366-374-specific response of non-Tg H2b mice, the magnitude was less. Using epitope prediction programs, we identified three novel B27-restricted influenza A epitopes, PB2.702-710, PB1.571-579, and PB2.368-376, recognized during both the primary and secondary response to infection. Although the secondary NP.383-391-specific response was dominant, PB1.571-579 and PB2.368-376 stimulated stronger proliferative expansion in memory T cells. Our results indicate a broader B27/influenza A CTL repertoire than previously known. Together with results for other HLA class I alleles, this information will become important in improving vaccine strategies for influenza A and other human pathogens."xsd:string |
| http://purl.uniprot.org/citations/16054612 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellimm.2005.06.004"xsd:string |
| http://purl.uniprot.org/citations/16054612 | http://purl.uniprot.org/core/author | "Cheuk E."xsd:string |
| http://purl.uniprot.org/citations/16054612 | http://purl.uniprot.org/core/author | "Chamberlain J.W."xsd:string |
| http://purl.uniprot.org/citations/16054612 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16054612 | http://purl.uniprot.org/core/name | "Cell Immunol"xsd:string |
| http://purl.uniprot.org/citations/16054612 | http://purl.uniprot.org/core/pages | "110-123"xsd:string |
| http://purl.uniprot.org/citations/16054612 | http://purl.uniprot.org/core/title | "Strong memory CD8+ T cell responses against immunodominant and three new subdominant HLA-B27-restricted influenza A CTL epitopes following secondary infection of HLA-B27 transgenic mice."xsd:string |
| http://purl.uniprot.org/citations/16054612 | http://purl.uniprot.org/core/volume | "234"xsd:string |
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