| http://purl.uniprot.org/citations/16055439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16055439 | http://www.w3.org/2000/01/rdf-schema#comment | "Insulin gene expression is regulated by pancreatic beta cell-specific factors, PDX-1 and BETA2/E47. Here we have demonstrated that the insulin promoter is a novel target for SREBPs established as lipid-synthetic transcription factors. Promoter analyses of rat insulin I gene in non-beta cells revealed that nuclear SREBP-1c activates the insulin promoter through three novel SREBP-binding sites (SREs), two of which overlap with E-boxes, binding sites for BETA2/E47. SREBP-1c activation of the insulin promoter was markedly enhanced by co-expression of BETA2/E47. This synergistic activation by SREBP-1c/BETA2/E47 was not mediated through SREs but through the E-boxes on which BETA2/E47 physically interacts with SREBP-1c, suggesting a novel function of SREBP as a co-activator. These two cis-DNA regions, E1 and E2, with an appropriate distance separating them, were mandatory for the synergism, which implicates formation of SREBP-1c.BETA2.E47 complex in a DNA looping structure for efficient recruitment of CREB-binding protein/p300. However, in the presence of PDX1, the synergistic action of SREBP-1c with BETA2/E47 was canceled. SREBP-1c-mediated activation of the insulin promoter and expression became overt in beta cell lines and isolated islets when endogenous PDX-1 expression was low. This cryptic SREBP-1c action might play a compensatory role in insulin expression in diabetes with beta cell lipotoxicity."xsd:string |
| http://purl.uniprot.org/citations/16055439 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m506718200"xsd:string |
| http://purl.uniprot.org/citations/16055439 | http://purl.uniprot.org/core/author | "Yoshikawa T."xsd:string |
| http://purl.uniprot.org/citations/16055439 | http://purl.uniprot.org/core/author | "Yamada N."xsd:string |
| http://purl.uniprot.org/citations/16055439 | http://purl.uniprot.org/core/author | "Oka J."xsd:string |
| http://purl.uniprot.org/citations/16055439 | http://purl.uniprot.org/core/author | "Shimano H."xsd:string |
| http://purl.uniprot.org/citations/16055439 | http://purl.uniprot.org/core/author | "Sone H."xsd:string |
| http://purl.uniprot.org/citations/16055439 | http://purl.uniprot.org/core/author | "Ide T."xsd:string |
| http://purl.uniprot.org/citations/16055439 | http://purl.uniprot.org/core/author | "Murase T."xsd:string |
| http://purl.uniprot.org/citations/16055439 | http://purl.uniprot.org/core/author | "Ishibashi S."xsd:string |
| http://purl.uniprot.org/citations/16055439 | http://purl.uniprot.org/core/author | "Amemiya-Kudo M."xsd:string |
| http://purl.uniprot.org/citations/16055439 | http://purl.uniprot.org/core/author | "Matsuzaka T."xsd:string |
| http://purl.uniprot.org/citations/16055439 | http://purl.uniprot.org/core/author | "Osuga J."xsd:string |
| http://purl.uniprot.org/citations/16055439 | http://purl.uniprot.org/core/author | "Yahagi N."xsd:string |
| http://purl.uniprot.org/citations/16055439 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16055439 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/16055439 | http://purl.uniprot.org/core/pages | "34577-34589"xsd:string |
| http://purl.uniprot.org/citations/16055439 | http://purl.uniprot.org/core/title | "Sterol regulatory element-binding proteins activate insulin gene promoter directly and indirectly through synergy with BETA2/E47."xsd:string |
| http://purl.uniprot.org/citations/16055439 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/16055439 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16055439 |
| http://purl.uniprot.org/citations/16055439 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16055439 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4S1-mappedCitation-16055439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16055439 |
| http://purl.uniprot.org/uniprot/#_P56720-mappedCitation-16055439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16055439 |
| http://purl.uniprot.org/uniprot/#_A6KUI5-mappedCitation-16055439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16055439 |