| http://purl.uniprot.org/citations/16079135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16079135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16079135 | http://www.w3.org/2000/01/rdf-schema#comment | "Amphotericin B is a medically important antifungal antibiotic that is also active against human immunodeficiency virus, Leishmania parasites, and prion diseases. The therapeutic use of amphotericin B is restricted by severe side effects that can be moderated by liposomal formulation or structural alteration. Chemical modification has shown that suppression of charge on the exocyclic carboxyl group of amphotericin B substantially reduces toxicity. We report targeted deletions of the amphN cytochrome P450 gene from the chromosome of the amphotericin-producing bacterium Streptomyces nodosus. The mutant strains produced amphotericin analogues in which methyl groups replace the exocyclic carboxyl groups. These compounds retained antifungal activity and had reduced hemolytic activity."xsd:string |
| http://purl.uniprot.org/citations/16079135 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.M506689200"xsd:string |
| http://purl.uniprot.org/citations/16079135 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m506689200"xsd:string |
| http://purl.uniprot.org/citations/16079135 | http://purl.uniprot.org/core/author | "Murphy B."xsd:string |
| http://purl.uniprot.org/citations/16079135 | http://purl.uniprot.org/core/author | "Murphy B."xsd:string |
| http://purl.uniprot.org/citations/16079135 | http://purl.uniprot.org/core/author | "Caffrey P."xsd:string |
| http://purl.uniprot.org/citations/16079135 | http://purl.uniprot.org/core/author | "Caffrey P."xsd:string |
| http://purl.uniprot.org/citations/16079135 | http://purl.uniprot.org/core/author | "Byrne B."xsd:string |
| http://purl.uniprot.org/citations/16079135 | http://purl.uniprot.org/core/author | "Byrne B."xsd:string |
| http://purl.uniprot.org/citations/16079135 | http://purl.uniprot.org/core/author | "Power P."xsd:string |
| http://purl.uniprot.org/citations/16079135 | http://purl.uniprot.org/core/author | "Power P."xsd:string |
| http://purl.uniprot.org/citations/16079135 | http://purl.uniprot.org/core/author | "Rawlings B."xsd:string |
| http://purl.uniprot.org/citations/16079135 | http://purl.uniprot.org/core/author | "Rawlings B."xsd:string |
| http://purl.uniprot.org/citations/16079135 | http://purl.uniprot.org/core/author | "Carmody M."xsd:string |
| http://purl.uniprot.org/citations/16079135 | http://purl.uniprot.org/core/author | "Carmody M."xsd:string |
| http://purl.uniprot.org/citations/16079135 | http://purl.uniprot.org/core/author | "Rai D."xsd:string |
| http://purl.uniprot.org/citations/16079135 | http://purl.uniprot.org/core/author | "Rai D."xsd:string |
| http://purl.uniprot.org/citations/16079135 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16079135 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16079135 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/16079135 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/16079135 | http://purl.uniprot.org/core/pages | "34420-34426"xsd:string |
| http://purl.uniprot.org/citations/16079135 | http://purl.uniprot.org/core/pages | "34420-34426"xsd:string |