| http://purl.uniprot.org/citations/16081776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16081776 | http://www.w3.org/2000/01/rdf-schema#comment | "CD4+ T cells with a block in the NF-kappaB signaling pathway exhibit decreases in Th1 responses and diminished nuclear levels of multiple transactivating NF-kappaB/Rel/IkappaB proteins. To determine the lineage-intrinsic contributions of these transactivators to Th differentiation, T cells from mice deficient in specific subunits were cultured in exogenous cytokines promoting either Th1 or Th2 differentiation. RelB-deficient cells exhibited dramatic defects in Th1 differentiation and IFN-gamma production, whereas no consistent defect in either Th1 or Th2 responses was observed with c-Rel-deficient cells. In sharp contrast, Bcl-3-null T cells displayed no defect in IFN-gamma production, but their Th2 differentiation and IL-4, IL-5, and IL-13 production were significantly impaired. The absence of RelB led to a dramatic decrease in the expression of T-box expressed in T cells and Stat4. In contrast, Bcl-3-deficient cells exhibited decreased GATA-3, consistent with evidence that Bcl-3 can transactivate a gata3 promoter. These data indicate that Bcl-3 and RelB exert distinct and opposing effects on the expression of subset-determining transcription factors, suggesting that the characteristics of Th cell responses may be regulated by titrating the stoichiometry of transactivating NF-kappaB/Rel/IkappaB complexes in the nuclei of developing helper effector cells."xsd:string |
| http://purl.uniprot.org/citations/16081776 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.175.4.2102"xsd:string |
| http://purl.uniprot.org/citations/16081776 | http://purl.uniprot.org/core/author | "Hunter C."xsd:string |
| http://purl.uniprot.org/citations/16081776 | http://purl.uniprot.org/core/author | "Siebenlist U."xsd:string |
| http://purl.uniprot.org/citations/16081776 | http://purl.uniprot.org/core/author | "Boothby M.R."xsd:string |
| http://purl.uniprot.org/citations/16081776 | http://purl.uniprot.org/core/author | "Liou H.C."xsd:string |
| http://purl.uniprot.org/citations/16081776 | http://purl.uniprot.org/core/author | "Corn R.A."xsd:string |
| http://purl.uniprot.org/citations/16081776 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16081776 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16081776 | http://purl.uniprot.org/core/pages | "2102-2110"xsd:string |
| http://purl.uniprot.org/citations/16081776 | http://purl.uniprot.org/core/title | "Opposing roles for RelB and Bcl-3 in regulation of T-box expressed in T cells, GATA-3, and Th effector differentiation."xsd:string |
| http://purl.uniprot.org/citations/16081776 | http://purl.uniprot.org/core/volume | "175"xsd:string |
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