| http://purl.uniprot.org/citations/16086026 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16086026 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16086026 | http://www.w3.org/2000/01/rdf-schema#comment | "Eukaryotic cells coordinately regulate histone and DNA synthesis. In mammalian cells, most of the regulation of histone synthesis occurs post-transcriptionally by regulating the concentrations of histone mRNA. As cells enter S phase, histone mRNA levels increase, and at the end of S phase they are rapidly degraded. Moreover, inhibition of DNA synthesis causes rapid degradation of histone mRNAs. Replication-dependent histone mRNAs are the only metazoan mRNAs that are not polyadenylated. Instead, they end with a conserved stem-loop structure, which is the only cis-acting element required for coupling regulation of histone mRNA half-life with DNA synthesis. Here we show that regulated degradation of histone mRNAs requires Upf1, a key regulator of the nonsense-mediated decay pathway, and ATR, a key regulator of the DNA damage checkpoint pathway activated during replication stress."xsd:string |
| http://purl.uniprot.org/citations/16086026 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb972"xsd:string |
| http://purl.uniprot.org/citations/16086026 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb972"xsd:string |
| http://purl.uniprot.org/citations/16086026 | http://purl.uniprot.org/core/author | "Kaygun H."xsd:string |
| http://purl.uniprot.org/citations/16086026 | http://purl.uniprot.org/core/author | "Kaygun H."xsd:string |
| http://purl.uniprot.org/citations/16086026 | http://purl.uniprot.org/core/author | "Marzluff W.F."xsd:string |
| http://purl.uniprot.org/citations/16086026 | http://purl.uniprot.org/core/author | "Marzluff W.F."xsd:string |
| http://purl.uniprot.org/citations/16086026 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16086026 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16086026 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/16086026 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/16086026 | http://purl.uniprot.org/core/pages | "794-800"xsd:string |
| http://purl.uniprot.org/citations/16086026 | http://purl.uniprot.org/core/pages | "794-800"xsd:string |
| http://purl.uniprot.org/citations/16086026 | http://purl.uniprot.org/core/title | "Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1."xsd:string |
| http://purl.uniprot.org/citations/16086026 | http://purl.uniprot.org/core/title | "Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1."xsd:string |
| http://purl.uniprot.org/citations/16086026 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/16086026 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/16086026 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16086026 |
| http://purl.uniprot.org/citations/16086026 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16086026 |
| http://purl.uniprot.org/citations/16086026 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16086026 |
| http://purl.uniprot.org/citations/16086026 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16086026 |
| http://purl.uniprot.org/uniprot/Q13315 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/16086026 |
| http://purl.uniprot.org/uniprot/Q92900 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/16086026 |