http://purl.uniprot.org/citations/16086288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/16086288 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveTo explore the value of reverse transcription-multiplex nested PCR in detecting MLL rearrangement in lzAML-M4/M5.MethodsBone marrow chromosome preparation was made using direct method or short-term culture. Karyotypic analysis was carried out by R-banding technique. Five common MLL fusion genes and MLL partial tandem duplication in 40 AML cases, including 12 M4 and 28 M5 were detected by reverse transcription(RT)-multiplex nested PCR.ResultsR-banding karyotypic analysis revealed 11q23 translocation including t(6;11)(q27;q23), t(9;11)(p21;q23), t(11;17)(q23;q21) and t(11;19)(q23;p13.1) in 7 cases. MLL rearrangements consisting of MLL/AF6 (1 case), MLL/AF9 (1 case), MLL/AF17 (2 cases), MLL/ELL (2 cases) and MLL partial tandem duplication(2 cases) were detected in 8 cases by RT-multiplex nested PCR. Among 8 cases with MLL rearrangement, 6 were chromosome translocation, 2 were MLL partial tandem duplication.ConclusionRT-multiplex nested PCR is a powerful technique in the detection of MLL rearrangement for tentativelly diagnosed AML-M4/M5."xsd:string |
http://purl.uniprot.org/citations/16086288 | http://purl.uniprot.org/core/author | "He J."xsd:string |
http://purl.uniprot.org/citations/16086288 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
http://purl.uniprot.org/citations/16086288 | http://purl.uniprot.org/core/author | "Wu Y.F."xsd:string |
http://purl.uniprot.org/citations/16086288 | http://purl.uniprot.org/core/author | "Pan J.L."xsd:string |
http://purl.uniprot.org/citations/16086288 | http://purl.uniprot.org/core/author | "Jiang H.Y."xsd:string |
http://purl.uniprot.org/citations/16086288 | http://purl.uniprot.org/core/author | "Xue Y.Q."xsd:string |
http://purl.uniprot.org/citations/16086288 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
http://purl.uniprot.org/citations/16086288 | http://purl.uniprot.org/core/name | "Zhonghua Yi Xue Yi Chuan Xue Za Zhi"xsd:string |
http://purl.uniprot.org/citations/16086288 | http://purl.uniprot.org/core/pages | "444-446"xsd:string |
http://purl.uniprot.org/citations/16086288 | http://purl.uniprot.org/core/title | "[Application of reverse transcription-multiplex nested PCR to detect MLL rearrangement in AML-M4/M5]."xsd:string |
http://purl.uniprot.org/citations/16086288 | http://purl.uniprot.org/core/volume | "22"xsd:string |
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