| http://purl.uniprot.org/citations/16091736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16091736 | http://www.w3.org/2000/01/rdf-schema#comment | "Nonsteroidal anti-inflammatory drugs (NSAIDs) including sulindac sulfide are known to exert cancer chemopreventative activity in a range of cell lines. This activity has been shown to involve the upregulation of the cyclin-dependent kinase inhibitor p21WAF1/CIP1. It is also known that NSAIDs can act as peroxisome proliferator-activated receptor (PPAR) agonists and antagonists. In this study, we show that sulindac sulfide acts both as a PPARgamma agonist and a PPARdelta antagonist in an immortalized prostatic epithelial cell line (PNT1A). We utilized siRNA technology to show that PPARgamma is required for both growth inhibition and p21WAF1/CIP1 upregulation in response to sulindac sulfide treatment in PNT1A cells. In addition, the overexpression of PPARdelta partially rescued these cells from growth inhibition and also dramatically inhibited sulindac sulfide-mediated p21WAF1/CIP1 upregulation. Together these data identify a novel link between PPARgamma/PPARdelta/p21WAF1/CIP1 and the cancer chemo-preventative properties of NSAIDs."xsd:string |
| http://purl.uniprot.org/citations/16091736 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1208983"xsd:string |
| http://purl.uniprot.org/citations/16091736 | http://purl.uniprot.org/core/author | "Palmer C.N."xsd:string |
| http://purl.uniprot.org/citations/16091736 | http://purl.uniprot.org/core/author | "Jarvis M.C."xsd:string |
| http://purl.uniprot.org/citations/16091736 | http://purl.uniprot.org/core/author | "Gray T.J."xsd:string |
| http://purl.uniprot.org/citations/16091736 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16091736 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/16091736 | http://purl.uniprot.org/core/pages | "8211-8215"xsd:string |
| http://purl.uniprot.org/citations/16091736 | http://purl.uniprot.org/core/title | "Both PPARgamma and PPARdelta influence sulindac sulfide-mediated p21WAF1/CIP1 upregulation in a human prostate epithelial cell line."xsd:string |
| http://purl.uniprot.org/citations/16091736 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/16091736 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16091736 |
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| http://purl.uniprot.org/uniprot/#_A0A0S2Z4K5-mappedCitation-16091736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16091736 |
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| http://purl.uniprot.org/uniprot/#_A0A494C1F9-mappedCitation-16091736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16091736 |
| http://purl.uniprot.org/uniprot/#_B6ZGS2-mappedCitation-16091736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16091736 |
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| http://purl.uniprot.org/uniprot/#_D2KUA6-mappedCitation-16091736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16091736 |
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| http://purl.uniprot.org/uniprot/#_F1D8S7-mappedCitation-16091736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16091736 |