| http://purl.uniprot.org/citations/16093393 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16093393 | http://www.w3.org/2000/01/rdf-schema#comment | "PolyADP-ribosylation is a transient posttranslational modification of proteins, mainly catalyzed by poly(ADP-ribose)polymerase-1 (PARP-1). This highly conserved nuclear protein is activated rapidly in response to DNA nick formation and promotes a fast DNA repair. Here, we examine a possible association between polyADP-ribosylation and the activity of neurotrophins and neuroprotective peptides taking part in life-or-death decisions in mammalian neurons. The presented results indicate an alternative mode of PARP-1 activation in the absence of DNA damage by neurotrophin-induced signaling mechanisms. PARP-1 was activated in rat cerebral cortical neurons briefly exposed to NGF-related nerve growth factors and to the neuroprotective peptides NAP (the peptide NAPVSIPQ, derived from the activity-dependent neuroprotective protein ADNP) and ADNF-9 (the peptide SALLRSIPA, derived from the activity-dependent neurotrophic factor ADNF) In addition, polyADP-ribosylation was involved in the neurotrophic activity of NGF-induced and NAP-induced neurite outgrowth in differentiating pheochromocytoma 12 cells as well as in the neuroprotective activity of NAP in neurons treated with the Alzheimer's disease neurotoxin beta-amyloid. A fast loosening of the highly condensed chromatin structure by polyADP-ribosylation of histone H1, which renders DNA accessible to transcription and repair, may underlie the role of polyADP-ribosylation in neurotrophic activity."xsd:string |
| http://purl.uniprot.org/citations/16093393 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.0333-05.2005"xsd:string |
| http://purl.uniprot.org/citations/16093393 | http://purl.uniprot.org/core/author | "Klein R."xsd:string |
| http://purl.uniprot.org/citations/16093393 | http://purl.uniprot.org/core/author | "Gozes I."xsd:string |
| http://purl.uniprot.org/citations/16093393 | http://purl.uniprot.org/core/author | "Steingart R.A."xsd:string |
| http://purl.uniprot.org/citations/16093393 | http://purl.uniprot.org/core/author | "Cohen-Armon M."xsd:string |
| http://purl.uniprot.org/citations/16093393 | http://purl.uniprot.org/core/author | "Priel E."xsd:string |
| http://purl.uniprot.org/citations/16093393 | http://purl.uniprot.org/core/author | "Visochek L."xsd:string |
| http://purl.uniprot.org/citations/16093393 | http://purl.uniprot.org/core/author | "Vulih-Shultzman I."xsd:string |
| http://purl.uniprot.org/citations/16093393 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16093393 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/16093393 | http://purl.uniprot.org/core/pages | "7420-7428"xsd:string |
| http://purl.uniprot.org/citations/16093393 | http://purl.uniprot.org/core/title | "PolyADP-ribosylation is involved in neurotrophic activity."xsd:string |
| http://purl.uniprot.org/citations/16093393 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/16093393 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16093393 |
| http://purl.uniprot.org/citations/16093393 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16093393 |
| http://purl.uniprot.org/uniprot/P27008#attribution-9F1F827237B4FE89DDD3A6E95CD9A0D0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16093393 |
| http://purl.uniprot.org/uniprot/#_P27008-mappedCitation-16093393 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16093393 |
| http://purl.uniprot.org/uniprot/#_Q9JKL8-mappedCitation-16093393 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16093393 |
| http://purl.uniprot.org/uniprot/Q9JKL8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16093393 |
| http://purl.uniprot.org/uniprot/P27008 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16093393 |