| http://purl.uniprot.org/citations/16096061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16096061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16096061 | http://www.w3.org/2000/01/rdf-schema#comment | "Coordination between cell proliferation and cell death is essential to maintain homeostasis in multicellular organisms. In Drosophila, these two processes are regulated by a pathway involving the Ste20-like kinase Hippo (Hpo) and the NDR family kinase Warts (Wts; also called Lats). Hpo phosphorylates and activates Wts, which in turn, through unknown mechanisms, negatively regulates the transcription of cell-cycle and cell-death regulators such as cycE and diap1. Here we identify Yorkie (Yki), the Drosophila ortholog of the mammalian transcriptional coactivator yes-associated protein (YAP), as a missing link between Wts and transcriptional regulation. Yki is required for normal tissue growth and diap1 transcription and is phosphorylated and inactivated by Wts. Overexpression of yki phenocopies loss-of-function mutations of hpo or wts, including elevated transcription of cycE and diap1, increased proliferation, defective apoptosis, and tissue overgrowth. Thus, Yki is a critical target of the Wts/Lats protein kinase and a potential oncogene."xsd:string |
| http://purl.uniprot.org/citations/16096061 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2005.06.007"xsd:string |
| http://purl.uniprot.org/citations/16096061 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2005.06.007"xsd:string |
| http://purl.uniprot.org/citations/16096061 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/16096061 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/16096061 | http://purl.uniprot.org/core/author | "Pan D."xsd:string |
| http://purl.uniprot.org/citations/16096061 | http://purl.uniprot.org/core/author | "Pan D."xsd:string |
| http://purl.uniprot.org/citations/16096061 | http://purl.uniprot.org/core/author | "Wu S."xsd:string |
| http://purl.uniprot.org/citations/16096061 | http://purl.uniprot.org/core/author | "Wu S."xsd:string |
| http://purl.uniprot.org/citations/16096061 | http://purl.uniprot.org/core/author | "Matthews K."xsd:string |
| http://purl.uniprot.org/citations/16096061 | http://purl.uniprot.org/core/author | "Matthews K."xsd:string |
| http://purl.uniprot.org/citations/16096061 | http://purl.uniprot.org/core/author | "Barrera J."xsd:string |
| http://purl.uniprot.org/citations/16096061 | http://purl.uniprot.org/core/author | "Barrera J."xsd:string |
| http://purl.uniprot.org/citations/16096061 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16096061 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16096061 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/16096061 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/16096061 | http://purl.uniprot.org/core/pages | "421-434"xsd:string |
| http://purl.uniprot.org/citations/16096061 | http://purl.uniprot.org/core/pages | "421-434"xsd:string |
| http://purl.uniprot.org/citations/16096061 | http://purl.uniprot.org/core/title | "The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP."xsd:string |
| http://purl.uniprot.org/citations/16096061 | http://purl.uniprot.org/core/title | "The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP."xsd:string |
| http://purl.uniprot.org/citations/16096061 | http://purl.uniprot.org/core/volume | "122"xsd:string |
| http://purl.uniprot.org/citations/16096061 | http://purl.uniprot.org/core/volume | "122"xsd:string |