| http://purl.uniprot.org/citations/16098524 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16098524 | http://www.w3.org/2000/01/rdf-schema#comment | "Wishful thinking (Wit) is a Drosophila transforming growth factor-beta (TGFbeta) superfamily type II receptor most related to the mammalian bone morphogenetic protein (BMP) type II receptor, BMPRII. To better understand its function, we undertook a biochemical approach to establish the ligand binding repertoire and downstream signaling pathway. We observed that BMP4 and BMP7, bound to receptor complexes comprised of Wit and the type I receptor thickveins and saxophone to activate a BMP-like signaling pathway. Further we demonstrated that both myoglianin and its most closely related mammalian ligand, myostatin, interacted with a Wit and Baboon (Babo) type II-type I receptor complex to activate TGFbeta/activin-like signaling pathways. These results thereby demonstrate that Wit binds multiple ligands to activate both BMP and TGFbeta-like signaling pathways. Given that myoglianin is expressed in muscle and glial-derived cells, these results also suggest that Wit may mediate myoglianin-dependent signals in the nervous system."xsd:string |
| http://purl.uniprot.org/citations/16098524 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2005.06.088"xsd:string |
| http://purl.uniprot.org/citations/16098524 | http://purl.uniprot.org/core/author | "Zhao X."xsd:string |
| http://purl.uniprot.org/citations/16098524 | http://purl.uniprot.org/core/author | "Attisano L."xsd:string |
| http://purl.uniprot.org/citations/16098524 | http://purl.uniprot.org/core/author | "Mehra A."xsd:string |
| http://purl.uniprot.org/citations/16098524 | http://purl.uniprot.org/core/author | "Lee-Hoeflich S.T."xsd:string |
| http://purl.uniprot.org/citations/16098524 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16098524 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/16098524 | http://purl.uniprot.org/core/pages | "4615-4621"xsd:string |
| http://purl.uniprot.org/citations/16098524 | http://purl.uniprot.org/core/title | "The Drosophila type II receptor, Wishful thinking, binds BMP and myoglianin to activate multiple TGFbeta family signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/16098524 | http://purl.uniprot.org/core/volume | "579"xsd:string |
| http://purl.uniprot.org/citations/16098524 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16098524 |
| http://purl.uniprot.org/citations/16098524 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16098524 |
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