| http://purl.uniprot.org/citations/16100040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16100040 | http://www.w3.org/2000/01/rdf-schema#comment | "The remodeling of ventricular gap junctions, as defined by changes in size, distribution, or function, is a prominent feature of diseased myocardium. However, the regulation of assembly and maintenance of gap junctions remains poorly understood. To investigate N-cadherin function in the adult myocardium, we used a floxed N-cadherin gene in conjunction with a cardiac-specific tamoxifen-inducible Cre transgene. The mutant animals appeared active and healthy until their sudden death approximately 2 months after deleting N-cadherin from the heart. Electrophysiologic analysis revealed abnormal conduction in the ventricles of mutant animals, including diminished QRS complex amplitude consistent with loss of electrical coupling in the myocardium. A significant decrease in the gap junction proteins, connexin-43 and connexin-40, was observed in N-cadherin-depleted myocytes. Perturbation of connexin function resulted in decreased ventricular conduction velocity, as determined by optical mapping. Our data suggest that perturbation of the N-cadherin/catenin complex in heart disease may be an underlying cause, leading to the establishment of the arrythmogenic substrate by destabilizing gap junctions at the cell surface."xsd:string |
| http://purl.uniprot.org/citations/16100040 | http://purl.org/dc/terms/identifier | "doi:10.1161/01.res.0000181132.11393.18"xsd:string |
| http://purl.uniprot.org/citations/16100040 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/16100040 | http://purl.uniprot.org/core/author | "Yu C."xsd:string |
| http://purl.uniprot.org/citations/16100040 | http://purl.uniprot.org/core/author | "Xiong Y."xsd:string |
| http://purl.uniprot.org/citations/16100040 | http://purl.uniprot.org/core/author | "Molkentin J.D."xsd:string |
| http://purl.uniprot.org/citations/16100040 | http://purl.uniprot.org/core/author | "Kostetskii I."xsd:string |
| http://purl.uniprot.org/citations/16100040 | http://purl.uniprot.org/core/author | "Radice G.L."xsd:string |
| http://purl.uniprot.org/citations/16100040 | http://purl.uniprot.org/core/author | "Patel V.V."xsd:string |
| http://purl.uniprot.org/citations/16100040 | http://purl.uniprot.org/core/author | "Morley G.E."xsd:string |
| http://purl.uniprot.org/citations/16100040 | http://purl.uniprot.org/core/author | "Chu A.F."xsd:string |
| http://purl.uniprot.org/citations/16100040 | http://purl.uniprot.org/core/author | "Jacobson J.T."xsd:string |
| http://purl.uniprot.org/citations/16100040 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16100040 | http://purl.uniprot.org/core/name | "Circ Res"xsd:string |
| http://purl.uniprot.org/citations/16100040 | http://purl.uniprot.org/core/pages | "474-481"xsd:string |
| http://purl.uniprot.org/citations/16100040 | http://purl.uniprot.org/core/title | "Cardiac-specific loss of N-cadherin leads to alteration in connexins with conduction slowing and arrhythmogenesis."xsd:string |
| http://purl.uniprot.org/citations/16100040 | http://purl.uniprot.org/core/volume | "97"xsd:string |
| http://purl.uniprot.org/citations/16100040 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16100040 |
| http://purl.uniprot.org/citations/16100040 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16100040 |
| http://purl.uniprot.org/uniprot/#_A0A286YDF7-mappedCitation-16100040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16100040 |
| http://purl.uniprot.org/uniprot/#_D3YYT0-mappedCitation-16100040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16100040 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P8A3-mappedCitation-16100040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16100040 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P793-mappedCitation-16100040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16100040 |
| http://purl.uniprot.org/uniprot/#_A0A654ICB8-mappedCitation-16100040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16100040 |