| http://purl.uniprot.org/citations/16100281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16100281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16100281 | http://www.w3.org/2000/01/rdf-schema#comment | "Kv4.3 inactivation is a complex multiexponential process, which can occur from both closed and open states. The fast component of inactivation is modulated by the N-terminus, but the mechanisms mediating the other components of inactivation are controversial. We studied inactivation of Kv4.3 expressed in Xenopus laevis oocytes, using the two-electrode voltage-clamp technique. Inactivation during 2000 ms pulses at potentials positive to the activation threshold was described by three exponents (46 +/- 3, 152 +/- 13, and 930 +/-50 ms at +50 mV, n = 7) whereas closed-state inactivation (at potentials below threshold) was described by two exponents (1079 +/- 119 and 3719 +/-307 ms at -40 mV, n = 9). The fast component of open-state inactivation was dominant at potentials positive to -20 mV. Negative to -30 mV, the intermediate and slow components dominated inactivation. Inactivation properties were dependent on pulse duration. Recovery from inactivation was strongly dependent on voltage and pulse duration. We developed an 11-state Markov model of Kv4.3 gating that incorporated a direct transition from the open-inactivated state to the closed-inactivated state. Simulations with this model reproduced open- and closed-state inactivation, isochronal inactivation relationships, and reopening currents. Our data suggest that inactivation can proceed primarily from the open state and that multiple inactivation components can be identified."xsd:string |
| http://purl.uniprot.org/citations/16100281 | http://purl.org/dc/terms/identifier | "doi:10.1529/biophysj.105.059378"xsd:string |
| http://purl.uniprot.org/citations/16100281 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/16100281 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/16100281 | http://purl.uniprot.org/core/author | "Morales M.J."xsd:string |
| http://purl.uniprot.org/citations/16100281 | http://purl.uniprot.org/core/author | "Morales M.J."xsd:string |
| http://purl.uniprot.org/citations/16100281 | http://purl.uniprot.org/core/author | "Rasmusson R.L."xsd:string |
| http://purl.uniprot.org/citations/16100281 | http://purl.uniprot.org/core/author | "Rasmusson R.L."xsd:string |
| http://purl.uniprot.org/citations/16100281 | http://purl.uniprot.org/core/author | "Strauss H.C."xsd:string |
| http://purl.uniprot.org/citations/16100281 | http://purl.uniprot.org/core/author | "Strauss H.C."xsd:string |
| http://purl.uniprot.org/citations/16100281 | http://purl.uniprot.org/core/author | "Bondarenko V.E."xsd:string |
| http://purl.uniprot.org/citations/16100281 | http://purl.uniprot.org/core/author | "Bondarenko V.E."xsd:string |
| http://purl.uniprot.org/citations/16100281 | http://purl.uniprot.org/core/author | "Qu Y.J."xsd:string |
| http://purl.uniprot.org/citations/16100281 | http://purl.uniprot.org/core/author | "Qu Y.J."xsd:string |
| http://purl.uniprot.org/citations/16100281 | http://purl.uniprot.org/core/author | "Bett G.C."xsd:string |
| http://purl.uniprot.org/citations/16100281 | http://purl.uniprot.org/core/author | "Bett G.C."xsd:string |
| http://purl.uniprot.org/citations/16100281 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16100281 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16100281 | http://purl.uniprot.org/core/name | "Biophys. J."xsd:string |
| http://purl.uniprot.org/citations/16100281 | http://purl.uniprot.org/core/name | "Biophys J"xsd:string |
| http://purl.uniprot.org/citations/16100281 | http://purl.uniprot.org/core/pages | "3026-3041"xsd:string |
| http://purl.uniprot.org/citations/16100281 | http://purl.uniprot.org/core/pages | "3026-3041"xsd:string |
| http://purl.uniprot.org/citations/16100281 | http://purl.uniprot.org/core/title | "Time- and voltage-dependent components of Kv4.3 inactivation."xsd:string |