| http://purl.uniprot.org/citations/16103164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16103164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16103164 | http://www.w3.org/2000/01/rdf-schema#comment | "By recruiting the positive transcriptional elongation factor b (P-TEFb) to paused RNA polymerase II, the transactivator Tat stimulates transcriptional elongation of the human immunodeficiency virus type 1 (HIV-1) genome. We found that cyclin-dependent kinase 9 (Cdk9), the catalytic subunit of P-TEFb, is ubiquitylated in vivo. This ubiquitylation depended on the Skp1/Cul1/F-box protein E3 ubiquitin ligase Skp2. Likewise, Tat required Skp2 since its transactivation of the HIV-1 long terminal repeat decreased in primary mouse embryonic fibroblasts, which lacked Skp2. The ubiquitylation of Cdk9 by Skp2 facilitated the formation of the ternary complex between P-TEFb, Tat, and transactivation response element. Thus, our findings underscore the requirement of ubiquitylation for the coactivator function in regulating HIV-1 transcriptional elongation."xsd:string |
| http://purl.uniprot.org/citations/16103164 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.79.17.11135-11141.2005"xsd:string |
| http://purl.uniprot.org/citations/16103164 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.79.17.11135-11141.2005"xsd:string |
| http://purl.uniprot.org/citations/16103164 | http://purl.uniprot.org/core/author | "Zhang F."xsd:string |
| http://purl.uniprot.org/citations/16103164 | http://purl.uniprot.org/core/author | "Zhang F."xsd:string |
| http://purl.uniprot.org/citations/16103164 | http://purl.uniprot.org/core/author | "Peterlin B.M."xsd:string |
| http://purl.uniprot.org/citations/16103164 | http://purl.uniprot.org/core/author | "Peterlin B.M."xsd:string |
| http://purl.uniprot.org/citations/16103164 | http://purl.uniprot.org/core/author | "Plemenitas A."xsd:string |
| http://purl.uniprot.org/citations/16103164 | http://purl.uniprot.org/core/author | "Plemenitas A."xsd:string |
| http://purl.uniprot.org/citations/16103164 | http://purl.uniprot.org/core/author | "Barboric M."xsd:string |
| http://purl.uniprot.org/citations/16103164 | http://purl.uniprot.org/core/author | "Barboric M."xsd:string |
| http://purl.uniprot.org/citations/16103164 | http://purl.uniprot.org/core/author | "Besenicar M."xsd:string |
| http://purl.uniprot.org/citations/16103164 | http://purl.uniprot.org/core/author | "Besenicar M."xsd:string |
| http://purl.uniprot.org/citations/16103164 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16103164 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16103164 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/16103164 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/16103164 | http://purl.uniprot.org/core/pages | "11135-11141"xsd:string |
| http://purl.uniprot.org/citations/16103164 | http://purl.uniprot.org/core/pages | "11135-11141"xsd:string |
| http://purl.uniprot.org/citations/16103164 | http://purl.uniprot.org/core/title | "Ubiquitylation of Cdk9 by Skp2 facilitates optimal Tat transactivation."xsd:string |
| http://purl.uniprot.org/citations/16103164 | http://purl.uniprot.org/core/title | "Ubiquitylation of Cdk9 by Skp2 facilitates optimal Tat transactivation."xsd:string |
| http://purl.uniprot.org/citations/16103164 | http://purl.uniprot.org/core/volume | "79"xsd:string |
| http://purl.uniprot.org/citations/16103164 | http://purl.uniprot.org/core/volume | "79"xsd:string |